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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1498139
This article is part of the Research Topic Multi-Omics in Head and Neck Cancer: Unveiling Immunological Biomarkers for Therapy View all articles

CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ

Provisionally accepted
Juan Tang Juan Tang 1Dongling Yu Dongling Yu 1Jiaojiao Song Jiaojiao Song 2Junfei Li Junfei Li 1Yijuan Zhang Yijuan Zhang 1Xiangrui Ma Xiangrui Ma 1Wenlong Wang Wenlong Wang 1*
  • 1 Binzhou Medical University Hospital, Binzhou, China
  • 2 Weihai Stomatological Hospital, Weihai, China

The final, formatted version of the article will be published soon.

    Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression. In this study, we collected cancerous and corresponding noncancerous tissues from five patients with HNSCC. We analy sed circRNA and mRNA expression profiles to predict potential circRNA-microRNA (miRNA)-mRNA interactions. We found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p. Our findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis f or further research on the role of circRNA in HNSCC.

    Keywords: Head and neck squamous cell carcinoma, Bioinformatics analysis, High throughput sequencing technology, circRNA, miRNA, 14-3-3ζ

    Received: 18 Sep 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Tang, Yu, Song, Li, Zhang, Ma and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenlong Wang, Binzhou Medical University Hospital, Binzhou, China

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