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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1495753

The Relationship between HYDIN and Fallopian Tubal Cilia Loss in Patients with Epithelial Ovarian Cancer

Provisionally accepted
Yuanli Guo Yuanli Guo 1Xinxin He Xinxin He 2Junfeng Liu Junfeng Liu 3Yanming Tan Yanming Tan 4Chao Zhang Chao Zhang 4Shan Chen Shan Chen 5*
  • 1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
  • 2 Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
  • 3 Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
  • 4 GenePlus-Shenzhen, Shenzhen, China
  • 5 Department of Gynecology, The Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangzhou, China

The final, formatted version of the article will be published soon.

    Primary cilia play an important role in the development of cancer by regulating signaling pathways.Several studies have demonstrated that women with BRCA mutations have, on average, 50% fewer ciliated cells compared with general women. However, the role of tubal cilia loss in the development of epithelial ovarian cancer (EOC) remains unclear. Few specific studies have been found in linking HYDIN, a ciliary defect-associated gene that encodes HYDIN axonemal central pair apparatus protein, which is involved in the transduction of Hedgehog (Hh) signal and is considered a cancer-associated antigen, to ovarian cancer. Therefore, our study aimed to investigate the correlation between HYDIN gene mutations and tubal cilia loss in EOC. To meet this aim, a whole-exome sequencing (WES), immunohistochemistry (IHC), western blot, and reverse transcription-quantitative (RT-q) PCR were performed in 80 patients with EOC and 50 cases of non-ovarian cancer to detect the mutations and expression of tubal ciliary marker, ciliary morphology, and abnormal rate. We found that the incidence of tubal cilia loss was higher in EOC group with decreased expression of HYDIN compared with the control group (P<0.05). This study suggests that tubal ciliary loss is evident in epithelial fallopian tube carcinoma, and ciliary cells may be involved in the occurrence and development of EOC, and ciliarelated gene HYDIN is expected to be a tumor marker for epithelial ovarian cancer.

    Keywords: Fallopian Tubes, Cilia, epithelial ovarian cancer, HYDIN, marker

    Received: 13 Sep 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Guo, He, Liu, Tan, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shan Chen, Department of Gynecology, The Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangzhou, China

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