Skip to main content

REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1495476

Prognostic Significance of p27 in Colorectal Cancer: A Meta-Analysis and Bioinformatics analysis

Provisionally accepted
Jing Zou Jing Zou Dong Wang Dong Wang Gaoping Yin Gaoping Yin Kexiang Lu Kexiang Lu Kaibin Chang Kaibin Chang He Li He Li *
  • Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China

The final, formatted version of the article will be published soon.

    Background: In the past, numerous investigations have delved into the influence of p27(p27kip) on the prognosis and clinicopathological characteristics of colorectal cancer (CRC), yielding conclusions that are not universally statistically significant, thus rendering the discourse rather contentious.We collected available articles published before August 2024 and extracted data to analyze the association between the expression of p27 and the prognosis and clinicopathological features of CRC. In addition, we used GEPIA, UALCAN and HPA to validate our results.Results:Through an extensive examination of four prominent databases, we identified a total of 21 original articles encompassing a cohort of 3378 patients. The findings indicated that low expression of p27 may lead to shorter overall survival (OS) (hazard ratio [HR] = 0.44, confidence interval [CI]: 0.31-0.61; Z = 4.89, p = 0.000) and disease-free survival (DFS) (HR = 0.40, CI: 0.28-0.59; Z = 4.75, p = 0.000). In addition, low expression of p27 predisposed tumors to the right colon(odds ratio[OR] = 0.61, CI: 0.46-0.82; Z = 3.32, p = 0.001) and limited tumor differentiation (OR = 0.56, CI: 0.41-0.77; Z = 3.62, p = 0.000) , but had no effect on TNM staging (OR = 0.80, CI: 0.52-1.22; Z = 1.05, p = 0.295), lymph node metastasis (OR=0.90, CI: 0.25-3.28; Z = 0.16, p = 0.876) and tumor size(OR = 0.94, CI: 0.54-1.65; Z = 0.21, p = 0.835). The results of the GEPIA and UALCAN showed that p27 had no effect on TNM staging, lymph node metastasis, DFS and OS, and there was no expression difference in tumor tissues and normal tissues. The findings from the HPA indicated there was lower expression of p27 in tumor tissues compare to normal tissues.Although we reached inconsistent results with bioinformatics analysis from this meta-analysis, we confirmed that low expression of p27 can adversely affect the prognosis of CRC patients and make a meaningful impact on a part of clinicopathological features in meta-analysis with abundant data. In the future,

    Keywords: p27, colorectal cancer, prognosis, Meta-analysis, Bioinformatics analysis

    Received: 12 Sep 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Zou, Wang, Yin, Lu, Chang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: He Li, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.