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REVIEW article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1491099

Progress on angiogenic and antiangiogenic agents in the tumor microenvironment

Provisionally accepted
Jian Xu Jian Xu 1,2Zhihua Tang Zhihua Tang 1,2*
  • 1 Shaoxing People's Hospital, Shaoxing, China
  • 2 Department of Pharmacy, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    The development of tumors and their metastasis relies heavily on the process of angiogenesis. When the volume of a tumor expands, the resulting internal hypoxic conditions trigger the body to enhance the production of various angiogenic factors. These include vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and transforming growth factor-α (TGF-α), all of which work together to stimulate the activation of endothelial cells and catalyze angiogenesis. Antiangiogenic therapy (AAT) aims to normalize tumor blood vessels by inhibiting these angiogenic signals. In this review, we will explore the molecular mechanisms of angiogenesis within the tumor microenvironment, discuss traditional antiangiogenic drugs along with their limitations, examine new antiangiogenic drugs and the advantages of combination therapy, and consider future research directions in the field of antiangiogenic drugs. This comprehensive overview aims to provide insights that may aid in the development of more effective anti-tumor treatments.

    Keywords: tumor1, angiogenic2, antiangiogenic agents3, anti-angiogenic drugs4, antiangiogenic therapy5

    Received: 04 Sep 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Xu and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhihua Tang, Department of Pharmacy, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.