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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1488143
This article is part of the Research Topic Comprehensive Treatment Strategy for Improving Surgical Resection Rate of Retroperitoneal Sarcomas View all 8 articles

Total Retroperitoneal Lipectomy Improves Prognosis in Patients with Primary Retroperitoneal Liposarcoma: A Comparative Study

Provisionally accepted
Haicheng Gao Haicheng Gao *Shibo Liu Shibo Liu *Wenjie Li Wenjie Li Boyuan Zou Boyuan Zou *Chengli Miao Chengli Miao *
  • International Hospital, Peking University, Beijing, China

The final, formatted version of the article will be published soon.

    Background: Retroperitoneal liposarcoma (RPLS) is the most common soft tissue sarcoma originating in the retroperitoneal space. Although surgery is the standard treatment, recurrence remains frequent. In this study, we aimed to explore the safety and efficacy of total (ipsilateral) retroperitoneal lipectomy (TRL) compared to traditional complete resection (CR) for primary RPLS.We retrospectively analyzed patients with primary RPLS treated at our center between January 2014 and December 2020. Univariate and multivariable Cox regression analyses assessed the impact of demographic, operative, and clinicopathological variables on recurrence-free survival (RFS) and overall survival (OS). Kaplan-Meier plots illustrated RFS and OS, and the log-rank test compared time-to-event distributions.Results: A total of 81 patients were included in the final analysis: 37 in the CR group and 44 in the TRL group. Demographic and clinicopathologic parameters were comparable between the two groups. Post-operative morbidity occurred in 30.9% of cases, with 15 (40.5%) in the CR group and 10 (22.7%) in the TRL group (P=0.086). There were 9 cases of severe complications at grade 3 or higher, with 5 cases in the CR group and 4 cases in the TRL group. There was no significant difference between the two groups (P=0.314). The TRL group demonstrated improved RFS and OS, particularly among dedifferentiated liposarcoma (DDLS) patients.Conclusions: Total retroperitoneal lipectomy (TRL) appears to be a safe procedure that enhances survival outcomes in patients with primary RPLS. Further studies are needed to validate these findings.

    Keywords: Retroperitoneal liposarcoma, total retroperitoneal lipectomy, Complete resection, prognosis, complication

    Received: 29 Aug 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Gao, Liu, Li, Zou and Miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haicheng Gao, International Hospital, Peking University, Beijing, China
    Shibo Liu, International Hospital, Peking University, Beijing, China
    Boyuan Zou, International Hospital, Peking University, Beijing, China
    Chengli Miao, International Hospital, Peking University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.