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CASE REPORT article

Front. Oncol.
Sec. Pediatric Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1487544

Rare cases of Second Recurrence of Nephroblastoma with MLLT1 Gene Mutation: case report and literature review

Provisionally accepted
Yiling Dai Yiling Dai Xin Chen Xin Chen *Guoqian He Guoqian He Ju Gao Ju Gao Xia Guo Xia Guo *
  • West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Nephroblastoma or Wilms tumor is the most common tumor of the urinary system in childhood. The survival rate can reach more than 90% after multidisciplinary treatment, but there is still a certain recurrence rate. In recent years, domestic and foreign scholars have analyzed the gene mutations related to the recurrence of nephroblastoma from the genetics or epigenetics perspective. But few reports on the relationship between MLLT1 and the pathogenesis have been reported, patients with MLLT1 gene mutations often associated with poor prognosis. In this case, we report the recurrence of nephroblastoma with MLLT1 gene mutation and review relevant literatures. The researches on molecular genetic mechanism will provide theoretical basis for early warning, optimize individualized treatment plan, and have important significance for improving the prognosis.

    Keywords: Nephroblastoma, Wilms Tumor, Recurrence, MLLT1 gene, Mutation

    Received: 28 Aug 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Dai, Chen, He, Gao and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin Chen, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Xia Guo, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China

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