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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1486389

Prognostic role of prognostic nutritional index in patients with bladder cancer: A systematic review and meta-analysis

Provisionally accepted
Jing Sun Jing Sun *Zhenzhen Li Zhenzhen Li Xiaming Zhu Xiaming Zhu
  • The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China

The final, formatted version of the article will be published soon.

    Aims: An increasing number of studies have explored the prognostic significance of the prognostic nutritional index (PNI) in bladder cancer patients, but the results are inconsistent. This study systematically investigates the prognostic value of baseline PNI in patients with bladder cancer through a meta-analytic approach.Methods: The databases of PubMed, EmBase, and the Cochrane library were systematically searched for eligible studies from inception until April 2024. The prognostic outcomes including overall survival (OS) and recurrence-free survival (RFS). The summary outcomes were calculated using the random-effects model, and the exploratory analyses were performed by sensitivity and subgroup analyses.Results: Twelve retrospective studies involved 2,951 patients with bladder cancer were selected in final analysis. The summary results found low PNI were associated with poor OS (HR: 1.80; 95%CI: 1.54-2.10; P<0.001) and RFS (HR: 1.53; 95%CI:1.15-2.04; P=0.003). The association between low PNI and shorter OS was statistically significant in all subgroups. Additionally, the association between low PNI and RFS was also significant in most subgroups.This study found a significant association between low PNI and poor prognosis in bladder cancer patients. Further large-scale prospective study should be performed to verify this association, and assess the nutrition interventions for patients with bladder cancer.

    Keywords: Prognostic nutritional index, Bladder cancer, overall survival, Recurrence-free survival, Meta-analysis

    Received: 26 Aug 2024; Accepted: 05 Dec 2024.

    Copyright: © 2024 Sun, Li and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jing Sun, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.