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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1484876

Safety and efficacy of combined acetabular reconstruction and microwave ablation in the treatment of periacetabular metastatic disease: a retrospective clinical evaluation

Provisionally accepted
Chuanxi Zheng Chuanxi Zheng 1Jin Qiu Jin Qiu 2*Xiayi Zhou Xiayi Zhou 1*Gang Xu Gang Xu 1*Tao Lan Tao Lan 3Shiquan Zhang Shiquan Zhang 1*Wei Li Wei Li 1*
  • 1 Department of Musculoskeletal Tumor Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
  • 2 National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Shenzhen, China
  • 3 Department of Spine Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China

The final, formatted version of the article will be published soon.

    The periacetabular bone defects caused by metastatic disease often necessitate acetabular reconstruction and various techniques have been employed with varying degrees of success. The purpose of this study was to evaluate the efficacy and safety of acetabular reconstruction in conjunction with adjuvant microwave ablation as a surgical intervention for patients with periacetabular metastases.Methods: Between January 2019 and September 2023, 17 consecutive patients with different tumor subtypes required surgical intervention for periacetabular metastases.The acetabular reconstruction was performed by utilizing an acetabular reconstructive cage and cement total hip arthroplasty with microwave ablation. A retrospective review was performed to assess pain relief, intraoperative details and postoperative complications. Functional status following procedures was determined by the 1993 Musculoskeletal Tumor Society (MSTS) score and the overall survival of patients was estimated by Kaplan-Meier analysis Results: In total, 8 males and 9 females were included with an average age of 48.6 years (range 34-66). Patients reported a significant improvement in the level of pain and the mean VAS score declined from 7.7 preoperatively to 2.2 postoperatively. Of the 17 patients, 16 could ambulate either independently (6 patients) or using a walking aid (10 patients) with a mean MSTS score of 18.9. The median follow-up was 9.0 months. Nine patients were alive at the most recent follow-up with overall survival of 40.9% at 12 months and 30.7% at 36 months, respectively.In selected patients with periacetabular metastasis, the utilization of an acetabular cage and cement total hip arthroplasty presents a less invasive reconstruction technique. The incorporation of adjuvant microwave ablation has shown promise in providing long-lasting pain relief, reducing intraoperative bleeding, and improving local tumor control. However, further research and extended follow-up are necessary to establish the effectiveness of this procedure.

    Keywords: acetabular metastasis, Microwave ablation, reconstruction, Surgery, metastasis

    Received: 22 Aug 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Zheng, Qiu, Zhou, Xu, Lan, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jin Qiu, National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Shenzhen, China
    Xiayi Zhou, Department of Musculoskeletal Tumor Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
    Gang Xu, Department of Musculoskeletal Tumor Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
    Shiquan Zhang, Department of Musculoskeletal Tumor Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
    Wei Li, Department of Musculoskeletal Tumor Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, China

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