Skip to main content

SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1484109

The relationship between metabolic syndrome and survival of patients with endometrial cancer: a meta-analysis

Provisionally accepted
Feng Deng Feng Deng Yi Chen Yi Chen *Ying Wu Ying Wu *Yawen Tang Yawen Tang *Wangjun Yi Wangjun Yi *
  • The Third Hospital of Changsha, Changsha, China

The final, formatted version of the article will be published soon.

    Background: Metabolic syndrome (MetS) is associated with a high risk of endometrial cancer (EC). However, its impact on EC progression remains unclear.This meta-analysis examined the association between MetS and survival outcomes in EC patients.A comprehensive search of PubMed, EMBASE, and Web of Science databases up to May 22, 2024, was conducted. Two independent reviewers performed study selection, data extraction, and quality assessment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using a random effects model.Results: Nine studies comprising 13,579 endometrial cancer (EC) patients were included. Among these, 2,896 patients (21.3%) had MetS at the time of enrollment.The follow-up durations ranged from 3.4 to 14.2 years. The results showed that EC patients with MetS at baseline demonstrated significantly poorer overall survival (HR = 1.57, 95% CI = 1.19-2.07, p = 0.002; I 2 = 25%) and progression-free survival (HR = 1.33, 95% CI = 1.08-1.63, p = 0.007; I 2 = 16%). A similar association was observed for cancer-specific survival (HR = 1.26, 95% CI = 1.10-1.44, p = 0.001; I 2 = 0%).Subgroup analyses based on study characteristics showed consistent results across studies conducted in countries with different follow-up durations.This meta-analysis suggests that MetS is associated with poor survival outcomes in EC patients. Further prospective studies are required to validate our findings.

    Keywords: metabolic syndrome, endometrial cancer, Survival, prognosis, meta-

    Received: 21 Aug 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Deng, Chen, Wu, Tang and Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yi Chen, The Third Hospital of Changsha, Changsha, China
    Ying Wu, The Third Hospital of Changsha, Changsha, China
    Yawen Tang, The Third Hospital of Changsha, Changsha, China
    Wangjun Yi, The Third Hospital of Changsha, Changsha, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.