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REVIEW article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1484027
This article is part of the Research Topic Comprehensive Treatment Strategy for Improving Surgical Resection Rate of Retroperitoneal Sarcomas View all 9 articles

Targeting Liposarcoma: Unveiling Molecular Pathways and Therapeutic Opportunities

Provisionally accepted
hong liang liu hong liang liu 1Xi Wang Xi Wang 1lingyan Liu lingyan Liu 2*Bingsong Yan Bingsong Yan 1*Fabo Qiu Fabo Qiu 3*Bin Zhou Bin Zhou 3*
  • 1 Qingdao Women and Children's Hospital, Qingdao, China
  • 2 Qilu Hospital, Shandong University, Jinan, Shandong Province, China
  • 3 The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma. We also discuss the clinical research progress of related targeted therapies, with an aim to provide a reference and crucial insights for colleagues in the field.

    Keywords: Liposarcoma, Driver genes, molecular pathogenesis, targeted therapy, Outlook

    Received: 21 Aug 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 liu, Wang, Liu, Yan, Qiu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    lingyan Liu, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
    Bingsong Yan, Qingdao Women and Children's Hospital, Qingdao, China
    Fabo Qiu, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China
    Bin Zhou, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.