Alicia B. Yang1
Amanda Leiter- 1Division of Endocrinology, Diabetes, and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- 2Division of General Internal Medicine Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Background: This brief report examines statin prescription trends for primary cardiovascular disease (CVD) prevention in breast cancer (BC) survivors with diabetes, a large population at particularly high CVD risk.
Methods: A population-based, retrospective cohort study was conducted using Surveillance, Epidemiology, and End Results (SEER) cancer registry data linked to Medicare claims. We identified women with preexisting diabetes who were diagnosed with stage 0–III primary BC between 2008 and 2017 without preexisting CVD. We assessed statin prescription rates over time and also examined differences in statin prescription rates according to patient sociodemographic characteristics. Using a multivariate logistic regression adjusted for sociodemographic and clinical variables, independent predictors of statin prescription were identified.
Results: Of 8,423 BC patients with diabetes without preexisting CVD, 5,698 (68%) had a statin prescription. Statin prescriptions increased over time (BC diagnosis year 2008–2009: 65%, 2010–2011: 67%, 2012–2013: 66%, 2014–2015: 69%, 2016–2017: 70%; p = 0.01) and differed by age (66–69: 66%, 70–74: 70%, 75–79: 69%, ≥80: 65%; p < 0.01) and race (White: 68%, Black: 62%, Latina: 66%, Other: 72%; p < 0.01). In a multivariate analysis, race (Black vs. White: OR 0.80, 95% CI: 0.68–0.95) remained a predictor of statin prescription.
Conclusion: In older early-stage BC survivors, statin prescriptions increased over time and varied by age, race, and BC stage. These findings can potentially inform strategies to improve guideline-concordant statin prescriptions in a group at high risk for CVD and reduce disparities.
Introduction
Patients with breast cancer (BC) and diabetes, a common comorbidity in BC with a prevalence of ~20%, are at particularly high risk of mortality and morbidity from cardiovascular disease (CVD) (1, 2). With advancements in BC screening and treatment, CVD is emerging as a leading cause of death in older early-stage BC survivors, the largest group of cancer survivors in the United States (>4 million) (1). BC survivors are at high CVD risk due to a high prevalence of CVD risk factors and exposure to cardiotoxic cancer treatments, including chemotherapy and radiation (3). Diabetes increases CVD mortality in this population even further (4). The prevalence of diabetes in BC survivors is increasing and disproportionately affects Black and Latina BC survivors, who also experience higher rates of CVD mortality after BC diagnosis (5–7).
Statins decrease CVD mortality in patients with both BC and diabetes and are important for survivorship care in this high-risk group (3, 8). In 2013, the American College of Cardiology broadened its guidelines to recommend statins for primary CVD prevention for almost all patients with diabetes ages 40–75 years, making >85% of patients with diabetes statin-eligible (8). However, little is known about statin prescription patterns in older BC survivors with diabetes since this paradigm change. As knowledge of statin prescription trends in BC survivors with diabetes is important for identifying care gaps and improving care in this population, we conducted a population-based, retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) cancer registry linked to Medicare claims.
Methods
We identified women diagnosed with stage 0–III primary BC (according to the American Joint Committee on Cancer criteria version 7) between 2008 and 2017, aged 66 and older, who had preexisting diabetes, had Medicare prescription data, had no preexisting CVD (myocardial infarction, congestive heart failure, peripheral vascular disease, and cerebrovascular disease), and were alive 1 year after BC diagnosis. Diagnosis of diabetes was defined by validated claims-based International Classification of Diseases (ICD) codes (9). Patient characteristics collected from SEER-Medicare included age at BC diagnosis, race/ethnicity, income (based on median income level from census tract or zip code), marital status, comorbidity burden, and claims for home health aide use (as a proxy for functional status). Race and marital status were obtained for the SEER registry through medical records review and are self-reported. Hispanic ethnicity was identified through algorithms incorporating birthplace and surname (10). Comorbidity burden was assessed by the modified Charlson comorbidity index (CCI) (excluding diabetes and cancer). CCI is a validated claims-based algorithm to assess comorbidity burden and is correlated with higher mortality risk (11, 12). Hyperlipidemia and hypertension were identified by claims codes validated in previous studies (13–15). Statin prescription was defined as at least one statin pharmacy claim within 1 year after BC diagnosis.
The chi-square test was used to compare demographic and clinical characteristics between patients who were and were not prescribed a statin. We used multiple logistic regression to determine independent predictors of statin prescription (a binary variable), as this method allowed us to account for variable confounding. We adjusted for variables known to influence statin prescriptions in previous literature, including age, race, income, diagnosis year, BC stage, CCI, hypertension, hyperlipidemia, BC stage, and diagnosis year (16, 17). p-values <0.05 were considered statistically significant. Analyses were conducted using SAS (version 9.4; SAS Institute, Inc., Cary, North Carolina, USA). The study was approved by Mount Sinai’s Institutional Review Board (#2201132).
Results
Of 48,273 women older than 66 years with stage 0–III primary BC diagnosed between 2008 and 2017 with Medicare prescription claims, 11,874 had preexisting diabetes (25%). After excluding 2,957 patients with preexisting CVD and 494 who died less than 1 year after BC diagnosis, 8,423 patients were eligible for analysis, of which 5,698 (68%) had a statin prescription (Table 1). Statin prescription differed by age (66–69 years: 66%, 70–74: 70%, 75–79: 69%, ≥80: 65%; p < 0.01) and race (White: 68%, Black: 62%, Latina: 66%, Other: 72%; p < 0.01), did not differ by comorbidity burden (CCI 0: 68%, 1–2: 67%, ≥3: 67%; p = 0.87), and decreased with higher BC stage (0: 73%, I: 70%, II: 65%, III: 63%; p < 0.01). Income and marital status did not differ significantly by statin prescription status (p > 0.05 for all comparisons). BC patients with hyperlipidemia (76% vs. 51% for no hyperlipidemia; p < 0.01) and hypertension (69% vs. 62% for no hypertension; p < 0.01) were more likely to be prescribed statins. Patients who received hormone therapy (69% vs. 65% for no hormone therapy; p < 0.01), radiation (69% vs. 65% for no radiation; p < 0.01), and surgery (68% vs. 63% for no surgery; p = 0.04) were also more likely to receive a statin prescription. However, patients treated with chemotherapy (65% vs. 68% for no chemotherapy; p < 0.01) were less likely to be prescribed a statin.
Table 1. Study cohort characteristics by statin prescription.
Statin prescriptions increased over our study period (BC diagnosis year 2008–2009: 65%, 2010–2011: 67%, 2012–2013: 66%, 2014–2015: 69%, 2016–2017: 70%; p = 0.01) (Figure 1). This trend was generally observed in all age categories except for patients 80 years and older. Patients who identified as White and other race had increased statin prescription frequencies over time. However, statin prescriptions for Black and Latina patients did not consistently increase over time, differing from the overall trend (Figure 1).
Figure 1. Statin prescription trends over time by age category and race: The black line shows the trend in statin prescription over time for the study cohort. The colored bars show the percentage of patients with at least one statin prescription during each 2-year period stratified by age category (A) and race (B).
In adjusted logistic regression (Figure 2), more recent BC diagnosis [2016–2017 vs. 2008–2009: odds ratio (OR): 1.19, 95% confidence interval (CI): 1.01–1.40], age group (70–74 vs. 66–69: OR: 1.19, 95% CI: 1.04–1.36), other race (OR: 1.22, 95% CI: 1.01–1.46 vs. White), and comorbid hyperlipidemia (OR: 3.02, 95% CI: 2.72–3.35) remained predictors of statin prescription. Black patients (OR: 0.80, 95% CI: 0.68–0.95 vs. White) were significantly less likely to receive a statin prescription.
Figure 2. Logistic regression plot: predictors of statin prescription. The adjusted odds ratio with 95% confidence intervals is presented. CCI, Charlson comorbidity index; CI, confidence interval; OR, odds ratio.
Discussion
In this nationally representative analysis of older early-stage BC patients with diabetes, statin prescription frequency for primary CVD prevention was 68% and increased between 2008 and 2017, but not for all age groups and races. As expected, the statin prescription rate in an older cohort with higher comorbidity burden was higher than what has been reported for a younger, healthier population with diabetes from 2015 to 2018 (55%) (16). Given the increased CVD risk of BC survivors with diabetes relative to survivors without diabetes, guideline-concordant statin prescription is critical in this population. This work highlights racial disparities in statin prescriptions for BC survivors. Our study reports lower prescription frequency in Black patients, which is consistent with racial disparities in statin use seen in the general diabetes population (16). Potential reasons for disparate statin prescriptions in Black patients include differences in patient beliefs regarding statin effectiveness, healthcare provider, mistrust, and financial barriers (18). Each of these presents critical opportunities for intervention and further research. Black BC survivors are at higher risk for CVD mortality than White BC survivors, especially within the first few years of diagnosis, highlighting the need for timely initiation of statins as investigated in this study (19). Elucidating statin prescription gaps for BC survivors is important for improving guideline-concordant preventive care and reducing BC survivorship disparities. Our analysis showed that statin use did not increase over time for patients ages 80 and older, reflecting a lack of clear benefit in this age group (8).
Although this study broadened the scope of previous literature on racial disparities in statin prescription, we recognize several limitations with this retrospective claims-based analysis. Comorbidities (e.g., diabetes, hyperlipidemia, and hypertension) and statin prescriptions were ascertained by insurance claims codes, which are subject to inaccuracies due to variation in healthcare provider billing practices. However, we used previously validated claims codes to enhance the accuracy of our findings. While claims codes accurately capture statin prescription patterns, they do not reflect statin utilization and adherence. Therefore, we cannot ascertain if statins were being taken as prescribed. We were not able to collect relevant biometrics, such as blood pressure and lipid levels. Therefore, we could not calculate 10-year atherosclerotic CVD risk and could not quantify what proportion of the study population truly qualified for a statin. However, we do know that >85% of patients with diabetes after 2013 are statin-eligible according to clinical guidelines (8). Another limitation with the SEER cancer registry is that race classifications rely largely on self-report, which can lead to incomplete race data and race misclassification. However, the SEER cancer registry has been shown to have complete and accurate race/ethnicity data compared to other large datasets (20). In future studies, with the increasing availability of genetic data, self-reported race/ethnicity data can be linked to genetic ancestry for a more complete picture of race/ethnicity. As this was a retrospective analysis, residual confounding may impact some of the associations that were identified. Despite these limitations, SEER-Medicare is one of the largest and most diverse validated databases, drawing valuable attention to nationwide trends and gaps in medical practice.
In summary, in a nationally representative cohort analysis of older patients with early-stage BC, statin prescriptions increased between 2008 and 2017 although there were racial disparities in statin prescription patterns. Further studies are needed to investigate the reasons for statin prescription disparities in patients with BC and diabetes and the impact of statin use on BC survivorship outcomes.
Data availability statement
Data used for this study are from SEER-Medicare, which is managed by the Centers for Medicare and Medicaid Services. While personal identifiers for medical providers and patients in the dataset have been removed, the data use agreement specifies that data cannot be shared publicly given the risk of re-identification (due to the large amount of available data). Data access can be facilitated, with appropriate approvals and data use agreement, from the Health Care Delivery Research Program at the National Cancer Institute. Requests to access these datasets should be directed to http://appliedresearch.cancer.gov/seermedicare/obtain/requests.html.
Ethics statement
The studies involving humans were approved by the Icahn School of Medicine at Mount Sinai Institutional Review Board 22-01132. The studies were conducted in accordance with the local legislation and institutional requirements. The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin. As retrospective data analysis involves no more than minimal risk, research could not practicably be carried out without the waiver or alteration.
Author contributions
AY: Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing. GM: Data curation, Writing – review & editing. CYK: Supervision, Funding acquisition, Writing – review & editing. JJL: Funding acquisition, Supervision, Writing – review & editing. JPW: Funding acquisition, Supervision, Writing – review & editing. AL: Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. AL received funding from NIH/NIDDK K08DK137022 and NIH/NCI T32CA225617. CYK, JJL, and JPW received funding from NIH/NCI R01CA271604.
Acknowledgments
This study used the linked SEER-Medicare database. The authors acknowledge the efforts of the National Cancer Institute; Information Management Services (IMS), Inc.; and the Surveillance, Epidemiology, and End Results (SEER) Program tumor registries in the creation of the SEER-Medicare database. The collection of cancer incidence data used in this study was supported by the California Department of Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease Control and Prevention’s (CDC) National Program of Cancer Registries, under cooperative agreement 1NU58DP007156; and the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program under contract HHSN261201800032I awarded to the University of California, San Francisco, contract HHSN261201800015I awarded to the University of Southern California, and contract HHSN261201800009I awarded to the Public Health Institute.
Conflict of interest
JPW reports consulting honoraria from Sanofi, Banook, and PPD and research grants from Sanofi, Regeneron, Axella, and Arnold Consultants, unrelated to the published work.
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
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Author disclaimer
The interpretation and reporting of these data are the sole responsibility of the authors. The ideas and opinions expressed herein are those of the author(s) and do not necessarily reflect the opinions of the State of California, Department of Public Health, the National Cancer Institute, and the Centers for Disease Control and Prevention or their Contractors and Subcontractors.
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Keywords: breast cancer, diabetes, statin, cardiovascular prevention, disparities (health racial), cancer survivor
Citation: Yang AB, Mhango G, Kong CY, Lin JJ, Wisnivesky JP and Leiter A (2024) Statin prescription disparities in patients with breast cancer and diabetes for primary cardiovascular disease prevention. Front. Oncol. 14:1483918. doi: 10.3389/fonc.2024.1483918
Received: 20 August 2024; Accepted: 09 October 2024;
Published: 06 November 2024.
Edited by:
Brijesh Patel, West Virginia University, United StatesReviewed by:
Huan Tao, Sichuan University, ChinaSreejata Raychaudhuri, University of Pittsburgh Medical Center, United States
Copyright © 2024 Yang, Mhango, Kong, Lin, Wisnivesky and Leiter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Amanda Leiter, QW1hbmRhLkxlaXRlckBtc3NtLmVkdQ==