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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1482817

Clinical analysis of molecular typing of 146 cases of endometrial carcinoma

Provisionally accepted
Bo Zhang Bo Zhang Dan Zhou Dan Zhou *Shuo Zhang Shuo Zhang Jinbowen Yan Jinbowen Yan Qingwei Meng Qingwei Meng *Qiubo Lv Qiubo Lv *
  • Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    To investigate the application of TCGA molecular typing in endometrial carcinoma, compare the relationship between molecular typing and clinicopathologic features, and provide a new idea for individual treatment of patients.Methods: A total of 146 EC patients who underwent surgical treatment and TCGA molecular typing in Beijing Hospital from December 2019 to March 2023 were collected. The clinicopathologic features, immunohistochemistry, and prognosis of the four TCGA molecular types were analyzed retrospectively.Result: Among the 146 patients with endometrial cancer (EC), 8 patients (5.5%) exhibited the POLE hypermutant type, 29 patients (19.9%) displayed the MSI-H type, 94 patients (64.4%) presented the low copy-number type, and 15 patients (10.3%) manifested the high copy-number type. A comparative analysis of the four TCGA types and age yielded statistically significant results (p = 0.012). Notably, significant associations were observed between menopausal status, the expression of ER, PR, and the four TCGA types. However, no significant difference was observed in CA125 levels before surgery among the four TCGA types (p = 0.587). There were significant differences observed among the four TCGA types and pathological types, pathological grades, FIGO stage, lymph node metastasis, and LVSI. The progression-free survival (PFS) rates of patients with POLE hypermutation, MSI-H type, CNL type, and CNH type were 100%, 100%, 93.62%, and 73.3%, respectively. There was a statistically significant difference between the four groups(p=0.006). POLE mutant and MSI-H type patients have higher PFS, while high copy type patients have the lowest.Conclusions: TCGA molecular typing has feasibility and application value in the clinical application of endometrial cancer, and has a certain predictive effect on the prognosis of EC patients. It has a certain guiding significance for the individual treatment of patients with endometrial cancer.

    Keywords: endometrial cancer, Molecular Typing, Clinical analysis, The prognosis, Individual treatment

    Received: 18 Aug 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Zhang, Zhou, Zhang, Yan, Meng and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dan Zhou, Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, 100006, Beijing Municipality, China
    Qingwei Meng, Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, 100006, Beijing Municipality, China
    Qiubo Lv, Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, 100006, Beijing Municipality, China

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