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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1482814

U-shaped relationship between serum uric acid and gastric cancer risk：A large prospective cohort study

Provisionally accepted
Junjun Huang Junjun Huang 1Ningning Mi Ningning Mi 2Jingli Yang Jingli Yang 3Ya Zheng Ya Zheng 4Jinqiu Jacky Yuan Jinqiu Jacky Yuan 5Wenbo Meng Wenbo Meng 2*
  • 1 First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
  • 2 The First Clinical Medical College, Lanzhou University, Lanzhou, China, Lan Zhou, China
  • 3 College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, Gansu Province, China
  • 4 Key Laboratory for Gastrointestinal Diseases, Gansu Province, Lanzhou University, Lanzhou, Gansu Province, China
  • 5 Clinical Research Center, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China

The final, formatted version of the article will be published soon.

    Objective: We conducted this study to investigate the relationship between serum uric acid (SUA) levels and the risk of upper gastrointestinal cancer.We conducted a prospective cohort study with 475659 cancer-free participants from the UK Biobank. All subjects were grouped into quartiles, and we used a Cox proportional hazards model to analyze the association between SUA levels and the risk of upper gastrointestinal cancer and explore the potential sex-specific relationship.Results: Of the 475659 participants, 883 eventually developed upper gastrointestinal cancers over a median follow-up period of 6.7 years. We observed that SUA level was positively correlated with the risk of female oral cancer (hazard ratio Quartile 4 vs Quartile 1 (95% CI): 2.05(1.03,4.06)) and negatively associated with the risk of esophageal cancer in the general population (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 0.65(0.45,0.93)). The risk of gastric cancer in males showed a U-shaped trend, decreasing and then increasing as SUA levels increased (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 0.51(0.32,0.81)). The risk of small intestine cancer in females showed a trend of increasing and then decreasing with increasing SUA levels (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 3.34(1.10,10.13)). Interaction analysis indicated that various factors, such as age, sex, smoking and drinking status, family history of cancer and BMI might play an important role in the relationship between SUA and cancer.SUA levels are positively associated with the risk of oral cancer risk in females and negatively associated with the risk of esophageal cancer in the general population. Both low and high SUA levels were associated with increased risk of gastric cancer, supporting a U-shaped association.

    Keywords: Upper gastrointestinal cancer, Uric Acid, UK Biobank, cohort study, U-shaped relationship

    Received: 18 Aug 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Huang, Mi, Yang, Zheng, Yuan and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenbo Meng, The First Clinical Medical College, Lanzhou University, Lanzhou, China, Lan Zhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.