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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1481885

Association between the expression of specific microRNAs and prostate cancer progression-A systematic review and meta-analysis

Provisionally accepted
Jihad Awadallah Alrehaili Jihad Awadallah Alrehaili 1,2*
  • 1 Imam Muhammad ibn Saud Islamic University, Riyadh, Saudi Arabia
  • 2 Department of Pathology, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    Background: This systematic review and metanalysis aimed to summarise the evidence supporting the significance of particular MiRNAs in PrCa progression and to thoroughly examine the body of prior research. Methods: In accordance with the PRISMA guidelines, this review was conducted using a specifically design data extraction protocol and searching several online databases for relevant articles. The protocol was registered in the PROSPERO database (CRD42023428460). Results: 8 studies were ultimately included in this review. MiRNAs significantly reduced PrCa proliferation, with an odds ratio (OR) of 0.28 (95% CI: 0.21–0.39) and a risk ratio (RR) of 0.51 (95% CI: 0.43–0.61), though moderate heterogeneity was observed (I² = 57%). For two studies investigating MiRNAs as biomarkers for predicting metastasis, the pooled OR was 0.60 (95% CI: 0.47–0.76) and the RR was 0.72 (95% CI: 0.62–0.84), both demonstrating significant predictive value with low heterogeneity (I² = 0%). Conclusion: The results emphasise the potential of miRNAs as biomarkers for predicting PrCa metastasis and demonstrate that miRNAs have a discernible effect on PrCa proliferation. However, to improve our comprehension of MiRNA's function in this condition, additional studies are required to address the limitations and investigate how MiRNA acts in many areas of PrCa.

    Keywords: microRNA, prostate cancer, metastasis, gene polymorphism, biomarker

    Received: 16 Aug 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Alrehaili. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jihad Awadallah Alrehaili, Imam Muhammad ibn Saud Islamic University, Riyadh, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.