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BRIEF RESEARCH REPORT article

Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1480793

Complex Karyotypes in Hematologic Disorders: a 12-Year Single-Center Study from Lebanon

Provisionally accepted
Souraya Rammal Souraya Rammal Farid Abou Abdallah Farid Abou Abdallah Charbel Attieh Charbel Attieh Zeinab El Mounajjed Zeinab El Mounajjed Warde Semaan Warde Semaan Alain CHEBLY Alain CHEBLY *
  • Center Jacques Loiselet for Medical Genetics and Genomics(CGGM), Faculty of Medicine, Saint Joseph University(USJ), Beirut, Lebanon

The final, formatted version of the article will be published soon.

    Conventional cytogenetic analysis is an important tool for the diagnosis of many hematologic disorders (HD). A karyotype is designed as « complex » when several alterations are detected.However, there is no clear consensus on the exact definition of a complex karyotype (CK), and there is a lack of studies that exclusively analyze CK in the literature. Complex karyotypes were analyzed over a period of 12 years at the Jacques Loiselet Center for Medical Genetics and Genomics (CGGM) at Saint Joseph University in Beirut (USJ) in Lebanon. 255 CK were analyzed with their associated chromosomal abnormalities (CA) detected. Out of 255 patients, 59.22% were males with a mean age of 59 years. The most common anomaly associated with CK was hyperdiploidy with a prevalence of 22.41%, which is different from a previously published study. To our knowledge, this represents the largest series of CK, particularly within the Middle East region. This study underscores the critical role of conventional cytogenetics in detecting CK, ultimately contributing to improved management of HD. Further investigations focusing on CK are needed.

    Keywords: hematologic disorders, Cytogenetics, complex karyotype, Chromosomal abnormalities, Karyotype, Lebanon

    Received: 14 Aug 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 Rammal, Abou Abdallah, Attieh, El Mounajjed, Semaan and CHEBLY. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alain CHEBLY, Center Jacques Loiselet for Medical Genetics and Genomics(CGGM), Faculty of Medicine, Saint Joseph University(USJ), Beirut, Lebanon

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