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PERSPECTIVE article

Front. Oncol.
Sec. Cancer Metabolism
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1480777
This article is part of the Research Topic Metastatic cancer: Cell behavior and the pre-metastatic niche View all 3 articles

Lung bronchiectasis as paradigm for the interplay between infection, colonization and plastic modulation of the pre-metastic niche

Provisionally accepted
Giulia M. Stella Giulia M. Stella *Lucreazia Pisanu Lucreazia Pisanu Klodyana Mucaj Klodyana Mucaj Valentina Conio Valentina Conio Francesco Bertuccio Francesco Bertuccio Ilaria Giana Ilaria Giana Lorenzo Arlando Lorenzo Arlando Marianna Russo Marianna Russo Simone Montini Simone Montini Chandra Bortolotto Chandra Bortolotto Angelo Corsico Angelo Corsico Klodjana Mucaj Klodjana Mucaj
  • University of Pavia, Pavia, Italy

The final, formatted version of the article will be published soon.

    The lungs are most often a preferential target organ for malignant spreading and growth. It is well known that chronic parenchymal inflammation and prolonged injuries represents an independent risk factor for cancer onset. Growing evidence supports the implication of lung microbiota in the pathogenesis of lung cancer. However, the full interplay between chronic inflammation, bacterial colonization, pathologic condition as bronchiectasis and malignant growth deserves better clarification. We here aim at presenting and analyzing original data and discussing the state-of-the-art on the knowledge regarding how this complex milieu acts on the plasticity of the lung pre-metastatic niche to point out the rationale for early diagnosis and therapeutic targeting.

    Keywords: Cancer, microbiome, Bronchiectasis, Pre-metastatic niche, Inflammation

    Received: 14 Aug 2024; Accepted: 24 Sep 2024.

    Copyright: © 2024 Stella, Pisanu, Mucaj, Conio, Bertuccio, Giana, Arlando, Russo, Montini, Bortolotto, Corsico and Mucaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Giulia M. Stella, University of Pavia, Pavia, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.