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REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1480683

Progress and perspectives on BMP9-ID1 activation of HIF-1α and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis

Provisionally accepted
Fei Ke Fei Ke 1Meng-Zhao Xu Meng-Zhao Xu 1*Bei-Bei He Bei-Bei He 2*Ji-De A Ji-De A 2*Long Ma Long Ma 2*Qi-Dong Chen Qi-Dong Chen 2*
  • 1 Qinghai University, Xining, China
  • 2 Qinghai Provincial People's Hospital, Xining, Qinghai Province, China

The final, formatted version of the article will be published soon.

    Hepatic alveolar echinococcosis is a zoonotic disease with a high incidence in western China, particularly affecting plateau areas such as Qinghai, Tibet, and Xinjiang. Research has indicated the presence of neovascularization in the peripheral infiltration area of hepatic alveolar echinococcosis, with a strong correlation between angiogenesis and vascular endothelial growth factor A (VEGFA) and hypoxia-inducible factor 1-alpha (HIF-1α) overexpression. Given the similarities between hepatic alveolar echinococcosis and liver cancer, current research is focused on treating the disease by targeting related signaling pathways using molecular drugs used for liver cancer. This article aims to summarize the biological regulation of HIF-1α and VEGFA overexpression in angiogenesis related to hepatic alveolar echinococcosis, as well as the impact of the BMP9-ID1 signaling pathway on the expression levels of HIF-1α and VEGFA, providing new insights for potential treatment strategies.

    Keywords: Bei-Bei He, Surgeon, general surgery, Qinghai Provincial People's Hospital, No. 2, Gonghe HIF-1α, VEGFA, BMP9, Id1, Angiogenesis, Hepatic alveolar echinococcosis

    Received: 20 Aug 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Ke, Xu, He, A, Ma and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Meng-Zhao Xu, Qinghai University, Xining, China
    Bei-Bei He, Qinghai Provincial People's Hospital, Xining, Qinghai Province, China
    Ji-De A, Qinghai Provincial People's Hospital, Xining, Qinghai Province, China
    Long Ma, Qinghai Provincial People's Hospital, Xining, Qinghai Province, China
    Qi-Dong Chen, Qinghai Provincial People's Hospital, Xining, Qinghai Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.