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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1480651

Diagnostic Accuracy of linked color imaging and white light imaging for Early Gastric Cancer and Gastrointestinal Metaplasia: A Systematic Review and Meta-Analysis

Provisionally accepted
Hui Duan Hui Duan *Xingxu Zhou Xingxu Zhou Qian Li Qian Li Liu Liu Liu Liu Qiong Wang Qiong Wang Kaiwen Wu Kaiwen Wu Lin Jiang Lin Jiang Xiaobin Sun Xiaobin Sun *
  • Chengdu Third People's Hospital, Chengdu, China

The final, formatted version of the article will be published soon.

    White light imaging (WLI) , linked color imaging (LCI) , gastric early cancer (EGC) , gastrointestinal metaplasia (GIM), detedtion rate Abatract: Background: Conventional white light imaging (WLI) frequently misses gastric cancer, resulting in a high rate of undiagnosed cases. This study compares the effectiveness of linked color imaging (LCI) and WLI in detecting early gastric cancer and gastrointestinal metaplasia, aiming to improve clinical diagnostic practices through evidence-based medical insights.Methods:The QUADAS-2 tool evaluated the quality of the studies. Additionally, methods like Split Component Synthesis (SCS) were utilized to evaluate the diagnostic performance of LCI and WLI.Results: Eleven studies involving a total of 7836 patients were included in the meta-analysis. Comparative analysis revealed that LCI demonstrated a statistically significant superiority over WLI in terms of the detection rates of EGC and GIM (detection rate of EGC: LCI vs WLI, 85% vs. 56.7%, p=0.004, OR 4.78, 95% CI 2.33-9.82, I2=71%; detection rate of GIM: LCI vs WLI, 88.9% vs. 40.1%, p=0.0003, OR 9.94, 95% CI 5.59-17.68, I2=71%). Additionally, LCI exhibited better sensitivity and specificity for the diagnosis of EGC and GIM compared to WLI. For the entire cohort, the sensitivity of LCI for EGC detection was 80% (95% CI 71%-86%) with a specificity of 82% (95% CI 63%-92%), while for GIM detection, the sensitivity was 87% (95% CI 81%-92%) with a specificity of 85% (95% CI 77%-91%).The detection efficiency of LCI for EGC and GIM is better than that of WLI, and LCI is recommended as the main screening method for EGC and GIM.

    Keywords: White light imaging (WLI), linked Color Imaging (LCI), gastric early cancer (EGC), gastrointestinal metaplasia (GIM), detedtion rate

    Received: 14 Aug 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Duan, Zhou, Li, Liu, Wang, Wu, Jiang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hui Duan, Chengdu Third People's Hospital, Chengdu, China
    Xiaobin Sun, Chengdu Third People's Hospital, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.