Skip to main content

MINI REVIEW article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1479454
This article is part of the Research Topic Editor's Challenge: Dr. Sara Pilotto - Modulating Tumor-Host Interplay through Lifestyle in Lung Cancer View all 3 articles

Exercise's Impact on Lung Cancer molecular mechanisms: A Current Overview

Provisionally accepted
Annamaria Mancini Annamaria Mancini 1,2Francesca Maria Orlandella Francesca Maria Orlandella 1,2Daniela Vitucci Daniela Vitucci 1,2Neila Luciano Neila Luciano 3Andreina Alfieri Andreina Alfieri 1,2Stefania Orrù Stefania Orrù 1,2Giuliana Salvatore Giuliana Salvatore 1,2*Pasqualina Buono Pasqualina Buono 1,2*
  • 1 University of Naples Parthenope, Naples, Italy
  • 2 CEINGE-Biotecnologie Avanzate “Franco Salvatore”, Napoli, Italy, Naples, Campania, Italy
  • 3 University of Naples Federico II, Naples, Campania, Italy

The final, formatted version of the article will be published soon.

    Lung cancer is the major cause of cancer-related deaths worldwide with an estimated 1.8 million deaths and 2.4 million new cases in 2022. Poor cardiorespiratory fitness, dyspnea and fatigue are the common features in lung cancer patients, partially limiting the exercise prescription. Exercise improves cardiorespiratory and muscular fitness and reduces the risk of some types of cancer, including lung cancer. Recently, the American Society of Clinical Oncology has encouraged preoperative exercise for lung cancer patients. Nonetheless, only limited data, mostly obtained from mouse models of lung cancer, are available on the molecular effects of exercise in lung cancer. Thus, the present minireview aims to shed light on the molecular mechanisms induced by different type of adapted exercise in lung cancer. In particular, the role of the exercise in tumor microenvironment remodeling, angiogenesis, gene expression, apoptosis and intermediate metabolism will be examined. The potential role of the exercise in combination with radiation therapy and immunotherapy on the cell growth modulation and response to the clinical treatment will be also discussed.

    Keywords: Exercise, lung cancer, Tumor Microenvironment, Angiogenesis, Gene Expression, Apoptosis, Intermediate metabolism

    Received: 12 Aug 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Mancini, Orlandella, Vitucci, Luciano, Alfieri, Orrù, Salvatore and Buono. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Giuliana Salvatore, University of Naples Parthenope, Naples, Italy
    Pasqualina Buono, University of Naples Parthenope, Naples, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.