Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Genetics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1478672
This article is part of the Research Topic The Physiological, pathological or pathophysiological characters for VRAC and its related genes View all 3 articles

A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer

Provisionally accepted
Haichao Li Haichao Li 1Yan Wang Yan Wang 1Daifang Chu Daifang Chu 1Jiangjiang Fan Jiangjiang Fan 1Ximing Zhu Ximing Zhu 1Yulong Ma Yulong Ma 2Zhongping Gu Zhongping Gu 1Nianlin Xie Nianlin Xie 1Pengyu Jing Pengyu Jing 1*
  • 1 Tangdu Hospital, Air Force Medical University, Xi'an, China
  • 2 Department of Thoracic Surgery, Yicheng County People's Hospital, Yicheng, China

The final, formatted version of the article will be published soon.

    The increasing incidence and mortality associated with lung cancer (LC) is a significant global health challenge. The underlying mechanisms contributing to LC remain inadequately understood. However, emerging evidence suggests that the epigenetic modifier protein arginine methyltransferase 5 (PRMT5) plays a complex role in various cellular processes, including DNA repair, gene transcription, and alternative splicing, through its function in catalyzing the symmetric dimethylation of both histone and non-histone proteins. In this study, we examined the functional role of PRMT5 utilizing LC-related datasets (GSE30219, GSE50081, and TCGA LC cohort) through a series of analyses.Our findings revealed that PRMT5 was significantly overexpressed in LC samples compared to normal tissues and was correlated with overall survival and disease-free survival rates. Additionally, PRDM1 was identified as a key protein exhibiting a strong interaction with PRMT5. The prognostic model that integrated PRMT5 with clinical factors demonstrated robust performance in assessing survival outcomes. Elevated levels of PRMT5 were associated with poor prognosis in LC, as evidenced by analyses of the GSE30219, GSE50081, and TCGA-LC datasets. Furthermore, we identified 27 ion channel (IC) genes exhibited a correlation with PRMT5 in lung adenocarcinoma (LUAD), of which 9 genes were identified as statistically significant with KM survival analysis.Strikingly, all of the 9 genes, including LRRC8A, the same as PRMT5, were 2 associated with poor prognosis in LUAD. Our research highlights the potential of PRMT5 as a novel prognostic biomarker and its relationship with IC genes in LC.

    Keywords: lung cancer, PRMT5, prognosis, epigenetics, Ion channel genes

    Received: 22 Aug 2024; Accepted: 07 Nov 2024.

    Copyright: © 2024 Li, Wang, Chu, Fan, Zhu, Ma, Gu, Xie and Jing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Pengyu Jing, Tangdu Hospital, Air Force Medical University, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.