The final, formatted version of the article will be published soon.
REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1478373
This article is part of the Research Topic DNA Damage, Repair and Mutagenesis: Targeting Cancer’s Achilles Heel View all 4 articles
Aldehyde-induced DNA-protein crosslinks-DNA damage, repair and mutagenesis
Provisionally accepted- Medical University of South Carolina, Charleston, United States
Aldehyde exposure has been shown to lead to the formation of DNA damage comprising of DNA-protein crosslinks (DPCs), base adducts and interstrand or intrastrand crosslinks. DPCs have recently drawn more attention because of recent advances in detection and quantification of these adducts. DPCs are highly deleterious to genome stability and have been shown to block replication forks, leading to wide-spread mutagenesis. Cellular mechanisms to prevent DPC-induced damage include excision repair pathways, homologous recombination, and specialized proteases involved in cleaving the covalently bound proteins from DNA. These pathways were first discovered in formaldehyde-treated cells, however, since then, various other aldehydes have been shown to induce formation of DPCs in cells. Defects in DPC repair or aldehyde clearance mechanisms lead to various diseases including Ruijs-Aalfs syndrome and AMeD syndrome in humans. Here, we discuss recent developments in understanding how aldehydes form DPCs, how they are repaired, and the consequences of defects in these repair pathways.
Keywords: DNA protein crosslink, Aldehydes, DNA Damage, DNA Repair, genome instability
Received: 09 Aug 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Blouin and Saini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Natalie Saini, Medical University of South Carolina, Charleston, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.