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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1477293
This article is part of the Research Topic Advances in Neoadjuvant Therapy for Head and Neck Squamous Cell Carcinoma View all 5 articles
Brucea javanica oil inhibited the Proliferation, Migration, and Invasion of Oral Squamous Carcinoma by regulated the MTFR2 pathway
Provisionally accepted
Wei Wang
1*
Yihan Lai
1
Mingkang Li
1*
Juan Zhan
1*
Lin Jiang
1*
Yuan Wu
1*
Zhiyi Fang
1*
Jianhan Zhou
2*
Yujie Ma
1*
Yisen Shao
1*- 1 Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
- 2 Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in oral and maxillofacial region. The development of new chemotherapy agents and new drug combinations may improve patient survival and quality of life, but both surgery and radiotherapy have significant functional side effects and drug resistance, ultimately resulting in a 5-year survival rate of no more than 60% for OSCC patients. Studies have shown that Brucea javanica oil (BJO) extracts have anti-cancer effects against a variety of cancers, but little research has been reported on OSCC. In this study, we concluded through in vitro and in vivo experiments that BJO may affect the SOD2/H2O2 signaling pathway by down-regulating MTFR2-mediated aerobic glycolysis, thereby inhibiting cell proliferation, Migration, and Invasion. The elucidation of this mechanism helps us to understand the molecular mechanism of inhibiting OSCC invasion and metastasis by BJO, which has important clinical value for improving the survival rate of OSCC patients.
Keywords: oral squamous cell carcinoma, Brucea javanica oil, MTFR2, SOD2/H2O2, Treatment
Received: 07 Aug 2024; Accepted: 16 Dec 2024.
Copyright: © 2024 Wang, Lai, Li, Zhan, Jiang, Wu, Fang, Zhou, Ma and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Wang, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Mingkang Li, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Juan Zhan, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Lin Jiang, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Yuan Wu, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Zhiyi Fang, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Jianhan Zhou, Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Yujie Ma, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Yisen Shao, Department of Oral and Maxillofacial Surgery, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
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