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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1475979

Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China

Provisionally accepted
Duanchong Zhao Duanchong Zhao 1Xingxing Yu Xingxing Yu 2Hongli Huang Hongli Huang 1Shuqing Zou Shuqing Zou 1Pingxiu Zhu Pingxiu Zhu 1Yuxiang Lin Yuxiang Lin 3Mengjie Song Mengjie Song 1Fangmeng Fu Fangmeng Fu 3Haomin Yang Haomin Yang 1,4*
  • 1 Fujian Medical University, Fuzhou, Fujian Province, China
  • 2 Jining Customs of the People's Republic of China, Jining, China
  • 3 Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China
  • 4 Karolinska Institutet (KI), Solna, Sweden

The final, formatted version of the article will be published soon.

    Background: Chemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.A case-control study was conducted in southeast China, including 1855 breast cancer patients and 1838 cancer-free controls. The association between single nucleotide polymorphisms (SNPs) in the CCL2 and CXCL12 genes and the susceptibility to breast cancer was investigated using logistic regression models. The association between plasma CCL2 and CXCL12 with breast cancer was further examined in 72 patients and 75 controls.The CXCL12 SNP rs3740085 was associated with breast cancer in the additive model (OR=1.15, 95%CI=1.01-1.32), particularly in postmenopausal women. The association between rs1024611 in CCL2 and breast cancer was only found in women with a BMI of ≥ 24kg/m2. SNPs in the CCL2 gene were mainly associated with PR-positive breast cancer, whereas rs1144471 in CXCL12 was associated with ER-negative (OR=0.43, 95% CI=0.23-0.84), PR-negative (OR=0.38, 95% CI=0.19-0.74), and HER-2-positive (OR=1.27, 95% CI=1.03-1.56) breast cancer. The interaction between rs1801157 and rs3740085 in CXCL12 SNPs was statistically significant, and rs3740085 was also associated with breast cancer survival. Additionally, we found a strong association between plasma CXCL12 and breast cancer.CCL2 and CXCL12 SNPs are associated with breast cancer susceptibility in overweight and postmenopausal women, and the effect varies according to subtypes. The interaction of SNPs within CXCL12 gene and the association with breast cancer survival further suggest potential targets for improved risk assessment and treatment strategies.

    Keywords: SNP, CCL2, CXCL12, breast cancer, chemokine

    Received: 04 Aug 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Zhao, Yu, Huang, Zou, Zhu, Lin, Song, Fu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Haomin Yang, Karolinska Institutet (KI), Solna, Sweden

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