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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1475052

The Correlation Study between Cervical Cancer and Sex Hormones

Provisionally accepted
Xian Wu Xian Wu 1,2*Yongpiao Ban Yongpiao Ban 2Yitao You Yitao You 2Yue Wen Yue Wen 3Yixian Ren Yixian Ren 4Dianhua Du Dianhua Du 2Yiping Wang Yiping Wang 2Bo Wang Bo Wang 2Wen Wu Wen Wu 2Lan Mo Lan Mo 2Xuelin Zhang Xuelin Zhang 2Chunwei Wu Chunwei Wu 2
  • 1 The affilited hospital of Guizhou Medical University, Guiyang, Guizhou, China
  • 2 Health Management Center, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou province, China., Guiyang, China
  • 3 Institute of Environmental and School Hygiene and Disinfection, Sichuan Center For Disease Control and Prevention, Chengdu 610041., Chengdu, China
  • 4 Twelfth Guangzhou City People's Hospital, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Objective The aim of this study was to investigate the association between positive TCT and sex hormone levels, and to evaluate the feasibility of change in sex hormone level as a potential predictor of cervical cancer.We recruited 910 female participants from the health examination center of a hospital in Guizhou between 2019 to 2023. All participants had undergone both hematologic examinations and cervical cancer screening.In total, 265 participants with positive TCT screening. 1. Luteinizing hormone, estradiol, prolactin and progesterone were negatively correlated with positive TCT screening; Age, systolic blood pressure, alanine aminotransferase, aspartate aminotransferase, urea, fasting blood glucose, low density lipoprotein, total cholesterol, triglyceride, erythrocyte, follicle stimulating hormone and testosterone were positively correlated with positive TCT screening. 2.Logistic regression analysis showed that prolactin, red blood cell count and age were risk factors for cervical cancer, while FSH was protective factor for cervical cancer. 3. AUC of FSH and age in prediction model were 0.701 and 0.705, respectively.

    Keywords: cervical cancer, Follicle-stimulating hormone, Prolactin, Thinprep Cytologic Test, sex hormones

    Received: 02 Aug 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Wu, Ban, You, Wen, Ren, Du, Wang, Wang, Wu, Mo, Zhang and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xian Wu, The affilited hospital of Guizhou Medical University, Guiyang, Guizhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.