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CASE REPORT article

Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1475036

Case Report: Successful Use of Ruxolitinib to Treat Interstitial Pneumonia as an Unusual Primary Presentation in Primary Myelofibrosis-Two Birds with One Stone

Provisionally accepted
Ping Ping Xiao Ping Ping Xiao *Zhigao Dong Zhigao Dong Qing Qing Wang Qing Qing Wang Jun Nan Su Jun Nan Su Yong Quan Chen Yong Quan Chen Yi Wan Lin Yi Wan Lin
  • Second Affiliated Hospital of Xiamen Medical College, Xiamen, China

The final, formatted version of the article will be published soon.

    Background: Interstitial lung disease (ILD) is a rare clinical presentation of primary myelofibrosis (PMF). Case presentation: We report a case of ILD as the main manifestation on admission. A 58year-old male was diagnosed with PMF owing to worsening anemia following treatment failure for conventional interstitial pneumonia. Results: Anemia and interstitial pneumonia both significantly improved following treatment with a Janus kinase 2 gene inhibitor. In this report, we discuss the possible mechanisms underlying PMF combined with ILD.

    Keywords: Interstitial pneumonia, Janus Kinase 2, Primary Myelofibrosis, Ruxolitinib, ten-eleven translocation methylcytosine dioxygenase 2

    Received: 05 Aug 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Xiao, Dong, Wang, Su, Chen and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ping Ping Xiao, Second Affiliated Hospital of Xiamen Medical College, Xiamen, China

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