Shuzhen Liu ^* Yuhui Nie Chen Song Kun Wu Mingxin Yu Xin Shen Yandong Bian

• Shandong Second Medical University, Weifang, China

Male breast cancer represents only 1% of all breast malignancies, with ecto pic breast cancer in men being even rarer and highly prone to diagnostic challenges. E xtramammary Paget's disease (EMPD), a rare cutaneous tumor with non-specific clini cal symptoms, is susceptible to misdiagnosis. This report discusses the case of an olde r male patient who presented with a scrotal mass, later identified as ectopic breast inva sive adenocarcinoma upon pathological examination post-lesion excision. Immunohis tochemistry confirmed a triple-negative profile and EMPD diagnosis, with no maligna ncies detected in either breast. Despite multiple treatment regimens and recurrence fol lowing adjuvant chemotherapy, the disease progressed with associated chemotherapyrelated side effects, resulting in a 25.5-month survival period. The scarcity of literature on male ectopic breast cancer complicates the understanding of its incidence and opti mal treatment strategies, increasing the risk of misdiagnosis. This study highlights the diagnostic and therapeutic challenges of this rare case, emphasizing the need for early recognition of atypical manifestations. The manuscript aims to assist clinicians by shar ing case-specific insights and reviewing pertinent literature to enhance comprehension and management of similarly rare cases.