Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1472190
This article is part of the Research Topic Incidence, Mortality, and Risk Factors for Oral Cancers View all 7 articles

Survival Outcomes and Contributing Factors in Oral Squamous Cell Carcinoma Patients in Khuzestan province, south west of Iran

Provisionally accepted
Babak Karimi Babak Karimi 1Arian Ghoreyshvandi Arian Ghoreyshvandi 1Maria Cheraghi Maria Cheraghi 2*
  • 1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Ahvaz, Khuzestan, Iran
  • 2 Social Determinants of Health Research Center, Department of Public Health, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Ahvaz, Khuzestan, Iran

The final, formatted version of the article will be published soon.

    Background: Oral Squamous Cell Carcinoma (OSCC) is the most frequent oral cancer worldwide. Even though Advances in OSCC Treatment, the mortality has not decreased in recent years. Therefore, the aim of this investigation was to assess the survival rate as a factor reflecting the quality aspects of care and background parameters that influence survival in patients with OSCC.Methods: This is a retrospective analysis of 165 patients with OSCC who were registered in the Khuzestan cancer registry system in 2014 to 2018. The data was collected in two parts: demographic information and survival information. Demographic and background variable including age, gender, marital status, ethnicity, employment status, insurance status, and educational status. Survival information was also collected through phone calls to patients or their families. The survival rate of the patients was analyzed using the log-rank test and the factors affecting were analyzed with the Cox Regression test.In this study, 165 patients, 43 women (26.1%) and 122 men (73.9%) with OSCC were included.The follow-up period of the patients was 5 years (2014-20149), during which 74 patients died.One, three, and five-year survival rates were 93.34%, 71.51%, and 44.84%, respectively. The results showed that age (χ2= 4.410, P<0.05) and employee status (χ2= 10.205, P<0.05)were associated with survival rate in OSCC patients based on the Log rank test results, while Cox regression analysis, after including all variables in the model and adjusting them, showed that all variables were not associated with survival rate (P>0.05).Since all background factors were not associated with survival rate, efforts should continue to identify effective factors and investigate the relationship between survival and pathological factors such as recurrence status, distant metastasis, type of treatment, and involved organs.

    Keywords: oral squamous cell carcinoma, OSCC, Survival, Cancer, Iran

    Received: 29 Jul 2024; Accepted: 22 Oct 2024.

    Copyright: © 2024 Karimi, Ghoreyshvandi and Cheraghi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Maria Cheraghi, Social Determinants of Health Research Center, Department of Public Health, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Ahvaz, Khuzestan, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.