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REVIEW article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1471978
This article is part of the Research Topic Management of Rare Oncological Cases View all 51 articles

A case of ovarian mesothelioma with VHL mutation diagnosed by immunohistochemistry and literature review

Provisionally accepted
Hao Yan Hao Yan 1Ye Yao Ye Yao 2,3Jing Xiong Jing Xiong 2,3*Qi Y. Duan Qi Y. Duan 4
  • 1 Hubei Cancer Hospital, Wuhan, Hubei Province, China
  • 2 Huazhong University of Science and Technology, Wuhan, China
  • 3 Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • 4 Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    The malignant mesothelioma mainly develops in pleura and peritoneum, while primary ovarian mesothelioma is very rare. Here, we report the first case of primary ovarian mesothelioma (clear cell variant) with VHL mutations in the world based on the results of histomorphology, Immunohistochemistry, and genetic testing. This is an extremely rare type of tumor that has not been reported so far. Through the literature search, we reviewed primary ovarian mesothelioma, focusing on its differential diagnosis and molecular genetics. The purpose of this paper is to deepen the flexible selection and application of immunohistochemical markers in mesothelioma, so as to reduce missed diagnosis and misdiagnosis.

    Keywords: Ovarian mesothelioma, ovarian clear cell tumor, differential diagnosis, VHL gene, Immunohistochemistry

    Received: 28 Jul 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Yan, Yao, Xiong and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jing Xiong, Huazhong University of Science and Technology, Wuhan, China

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