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PERSPECTIVE article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1471257
This article is part of the Research Topic Impacts of 2021 WHO Classification on the Precise Diagnosis and Management of Gliomas, Volume II View all articles

Toward Standardized Brain Tumor Tissue Processing Protocols in Neuro-Oncology: A Perspective for Gliomas and Beyond

Provisionally accepted
Analiz Rodriguez Analiz Rodriguez 1*Manmeet S. Ahluwalia Manmeet S. Ahluwalia 2,3,4Chetan Bettegowda Chetan Bettegowda 5Henry Brem Henry Brem 5Bob Carter Bob Carter 6Susan Chang Susan Chang 7Sunit Das Sunit Das 8Charles Eberhart Charles Eberhart 5Tomas Garzon-Muvdi Tomas Garzon-Muvdi 9Costas Hadjipanayis Costas Hadjipanayis 10Cynthia Hawkins Cynthia Hawkins 11Thomas S. Jacques Thomas S. Jacques 12,13Alexander Khalessi Alexander Khalessi 14Michael McDermott Michael McDermott 15Tom Mikkelsen Tom Mikkelsen 16Brent A. Orr Brent A. Orr 17Joanna Phillips Joanna Phillips 18Mark L. Rosenblum Mark L. Rosenblum 16William J. Shelton William J. Shelton 1David Solomon David Solomon 7Andreas von Deimling Andreas von Deimling 19Graeme F. Woodworth Graeme F. Woodworth 20James T. Rutka James T. Rutka 8
  • 1 University of Arkansas for Medical Sciences, Little Rock, United States
  • 2 Miami Cancer Institute, Baptist Hospital of Miami, Miami, Florida, United States
  • 3 Baptist Health South Florida, Miami, Florida, United States
  • 4 Florida International University, Miami, Florida, United States
  • 5 Johns Hopkins Medicine, Johns Hopkins University, Baltimore, Maryland, United States
  • 6 Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
  • 7 School of Medicine, University of California San Francisco, San Francisco, California, United States
  • 8 University of Toronto, Toronto, Ontario, Canada
  • 9 School of Medicine, Emory University, Atlanta, Georgia, United States
  • 10 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
  • 11 Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
  • 12 Developmental Biology and Cancer Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom
  • 13 Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
  • 14 UC San Diego Health, University of California, San Diego, San Diego, California, United States
  • 15 Miami Neuroscience Institute, South Miami, Florida, United States
  • 16 Henry Ford Health System, Detroit, Michigan, United States
  • 17 St. Jude Children's Research Hospital, Memphis, Tennessee, United States
  • 18 Helen Diller Family Comprehensive Cancer Center, Medical Center, University of California, San Francisco, San Francisco, California, United States
  • 19 Heidelberg University, Heidelberg, Baden-Württemberg, Germany
  • 20 School of Medicine, University of Maryland, Baltimore, Maryland, United States

The final, formatted version of the article will be published soon.

    Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendations on intraoperative tissue procurement only exist for diffuse gliomas but management of other brain tumor subtypes can also benefit from these protocols. Fresh tissue from surgical resection can now be used for intraoperative diagnostics and functional precision medicine assays. A multidisciplinary neuro-oncology perspective is critical to develop the best avenues for practical standardization. This perspective from the multidisciplinary Oncology Tissue Advisory Board (OTAB) discusses current advances, future directions, and the imperative of adopting standardized protocols for diverse brain tumor entities. There is a growing need for consistent operating room practices to enhance patient care, streamline research efforts, and optimize outcomes.

    Keywords: brain tumors, Biobank, tissue processing, precision medicine, gliomas

    Received: 26 Jul 2024; Accepted: 04 Sep 2024.

    Copyright: © 2024 Rodriguez, Ahluwalia, Bettegowda, Brem, Carter, Chang, Das, Eberhart, Garzon-Muvdi, Hadjipanayis, Hawkins, Jacques, Khalessi, McDermott, Mikkelsen, Orr, Phillips, Rosenblum, Shelton, Solomon, von Deimling, Woodworth and Rutka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Analiz Rodriguez, University of Arkansas for Medical Sciences, Little Rock, United States

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