Xinyue Gou
1
Xudong Tang
2*
Zhuo Chen
2*The final, formatted version of the article will be published soon.
REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1469178
Ferroptosis: A new mechanism of traditional Chinese medicine for treating hematologic malignancies
Provisionally accepted- 1 China Academy of Chinese Medical Sciences, Beijing, China
- 2 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Ferroptosis is a recently identified form of cell death characterized by lipid peroxidation and elevated iron levels. It is closely associated with hematologic malignancies, including leukemia, multiple myeloma (MM), and myelodysplastic syndromes (MDS). Research indicates that ferroptosis could represent a novel therapeutic target for these hematologic malignancies. Furthermore, traditional Chinese medicine (TCM) has been shown to modulate hematologic malignancies through the ferroptosis pathway. This paper aims to elucidate the mechanisms underlying ferroptosis and summarize the current research advancements regarding ferroptosis in hematologic malignancies, as well as the role of traditional Chinese medicine in the prevention and treatment of ferroptosis, with the goal of enhancing
Keywords: ferroptosis, Leukemia, Myelodysplastic Syndromes, Chinese medicine, hematologic malignancies
Received: 23 Jul 2024; Accepted: 30 Aug 2024.
Copyright: © 2024 Gou, Tang, Liu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xudong Tang, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Chi Liu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Zhuo Chen, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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