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STUDY PROTOCOL article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1467517
This article is part of the Research Topic Formation of Immunological Niches in Tumor Microenvironments: Mechanisms and Therapeutic Potential View all 8 articles

Expression and clinical significance of Numb and Notch-1 proteins between tissue of Colon cancer and Regional lymph node metastases

Provisionally accepted
Jingyou Ma Jingyou Ma *Jinpeng Zhen Jinpeng Zhen Ningbao Yang Ningbao Yang Changjuan Meng Changjuan Meng Yanjun Lian Yanjun Lian
  • Xingtai Central Hospital, Xingtai, China

The final, formatted version of the article will be published soon.

    Objective：To investigate the expression and clinical significance of Notch-1 and Numb protein in colon cancer tissues and regional lymph node metastases. Methods：Immunohistochemical method was used to detect the expression of Notch-1 protein and Numb protein in 110 cases of colon cancer tissues, along with tumor adjacent tissues and 56 cases of MLN tissues, and to analyze its role in colon cancer and MLN tissue. Results:Compared colon cancer tissue or lymph node metastases with tumor adjacent tissue,the positive expression rate of Numb was significantly decreased,while the positive expression of Notch-1 was significantly increased in colon cancer tissue or lymph node metastases(both P<0.05). The expression of Notch-1 and Numb was correlated with the lymph node metastasis, TNM stage and degree of differentiation (P<0.05). The expression between Numb and Notch-1 showed negative correlation in colon cancer tissues(r=-0.261 ，P<0.05). There was no relationship between the expression of Numb and Notch-1 protein in colon cancer and metastatic lymph node tissue(p>0.05).cancer tissue and metastatic lymph node tissue,suggesting that the interaction between the two proteins may play a promote role in the development,invasion and metastasis of colon cancer.There was no relationship between the expression of Numb and Notch-1 protein in colon cancer and metastatic lymph node tissue,suggesting that there is no obvious enhancement of the cancer cells,in the process of lymph node metastasis,the degree of malignant biological behavior remain relatively stable.

    Keywords: Colon cancer tissue, Metastatic lymph node tissue, tumor adjacent tissue, Notch-1 protein, Numb protein

    Received: 20 Jul 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Ma, Zhen, Yang, Meng and Lian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jingyou Ma, Xingtai Central Hospital, Xingtai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.