Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1466196

Major and minor perineural invasion in salivary gland cancer

Provisionally accepted
Suping Wang Suping Wang 1,2*Fei Liu Fei Liu 2Yinglin Chu Yinglin Chu 2Qizhe Zheng Qizhe Zheng 2Yunshuang Hu Yunshuang Hu 2Yiyi Wang Yiyi Wang 2Lu Qin Lu Qin 2Shuaikun Fu Shuaikun Fu 3
  • 1 China Medical University, Shenyang, China
  • 2 Zhengzhou University, Zhengzhou, Henan Province, China
  • 3 Xinxiang Medical University, Xinxiang, Henan Province, China

The final, formatted version of the article will be published soon.

    To delineate the distribution of perineural invasion (PNI), evaluate its impact on patient survival, and identify optimal criteria for initiating adjuvant radiation therapy (RT) in cases of PNI associated with salivary gland cancer (SGC). Methods: This retrospective study categorized enrolled patients into three groups based on PNI status (none, minor, or major), defined by the extent of nerve involvement. The influence of PNI on overall survival and locoregional control was assessed using a Cox proportional hazards model. Results: A total of 555 patients were incorporated into the study. Logistic regression analysis indicated that tumor stage, neck stage, histological grade, and pathological type were independently linked to the occurrence of PNI. In the Cox model assessing overall survival, patients exhibiting minor nerve PNI demonstrated a hazard ratio (HR) of 1.78 [95% CI: 1.14-2.47] in comparison to those without PNI, a difference that was statistically significant (p<0.001). Conversely, the variation in HR between patients with major nerve PNI and those with minor nerve PNI was not statistically significant (p=0.673). In the Cox model for locoregional control, patients with minor and major nerve PNI exhibited HRs of 1.64 [95%

    Keywords: Salivary gland cancer, Perineural invasion, adjuvant radiotherapy, chemoradiation, Survival

    Received: 17 Jul 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Wang, Liu, Chu, Zheng, Hu, Wang, Qin and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Suping Wang, China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.