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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1465052

Diagnostic trap: metastatic endometrial stromal sarcoma with breast metastasis

Provisionally accepted
Shuai Luo Shuai Luo *Xiaoxue Tian Xiaoxue Tian *Ting Xu Ting Xu *Jinjing Wang Jinjing Wang *
  • Affiliated Hospital of Zunyi Medical University, Zunyi, China

The final, formatted version of the article will be published soon.

    Background:Endometrial stromal sarcoma (ESS) is a rare type of uterine malignancy typically classified into low-grade ESS (LG-ESS) and high-grade ESS. LG-ESS is characterized by low malignancy and limited metastasis, primarily to the lungs. Metastasis of the breast is extremely rare, posing significant challenges in clinical diagnosis and treatment. Case demonstration: A 33-year-old female with a history of two cesarean sections was diagnosed with uterine LG-ESS five months prior. She was admitted for the excision of a left breast mass discovered during a routine examination. A histopathological biopsy confirmed the mass as a breast metastasis of LG-ESS. Postoperatively, she underwent radiotherapy and chemotherapy at a cancer hospital. She has been followed up on for two years with no recurrence. Conclusions: ESS with breast metastasis is extremely rare. The morphological features of ESS with breast metastasis can resemble mesenchymal and sex cord-stromal tumors, complicating imaging and pathological diagnosis, especially if there is no known history of uterine ESS. This study highlights the clinicopathological features of LG-ESS with breast metastasis, including clinical manifestations, imaging features, histopathology, immunohistochemistry, molecular genetic features, and treatment prognosis. It aims to provide new insights for the clinical diagnosis and treatment of ESS with breast metastasis.

    Keywords: Endometrial stromal sarcoma, metastasis, mammary gland, diagnosis, Treatment

    Received: 22 Jul 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Luo, Tian, Xu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shuai Luo, Affiliated Hospital of Zunyi Medical University, Zunyi, China
    Xiaoxue Tian, Affiliated Hospital of Zunyi Medical University, Zunyi, China
    Ting Xu, Affiliated Hospital of Zunyi Medical University, Zunyi, China
    Jinjing Wang, Affiliated Hospital of Zunyi Medical University, Zunyi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.