Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Breast Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1464909
This article is part of the Research Topic Multidisciplinary and Personalized Approach in the Treatment of Advanced Breast Cancer View all 11 articles

Triggered ferroptotic albumin-tocopherol nanocarriers for treating drug-resistant breast cancer

Provisionally accepted
Qianqian Gao Qianqian Gao Tingting Liu Tingting Liu Li Sun Li Sun YONGLIANG YAO YONGLIANG YAO Fang Li Fang Li Lingxiang Mao Lingxiang Mao *
  • Affiliated Kunshan hospital of Jiangsu University, suzhou, China

The final, formatted version of the article will be published soon.

    Ferroptosis is considered an effective method to overcome drug-resistant tumors. This study aims to use three FDA-approved biological materials, human serum albumin, D-α-tocopherol succinate, and indocyanine green, to construct a novel biocompatible nanomaterial named HTI-NPs, exploring its effect in drug-resistant breast cancer (MCF-7/ADR cells). The research results indicate that HTI-NPs can selectively inhibit the proliferation of MCF-7/ADR cells in vitro, accompanied by upregulating transferrin receptor, generating reactive oxygen species, and downregulating glutathione peroxidase 4. Under laser irradiation, HTI-NPs can promote ferroptosis by inhibiting glutathione expression through photodynamic therapy. Notably, HTI-NPs exhibit good inhibitory effects on MCF-7/ADR xenograft tumors in vivo. In conclusion, HTI-NPs represent a biocompatible nanomaterial that induces ferroptosis, providing new insights and options for treating drug-resistant breast cancer.

    Keywords: ferroptosis, Photodynamic therapy, Biocompatibility, drug-resistant breast cancer, albumin nanocarrier, Indocyanine Green

    Received: 15 Jul 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Gao, Liu, Sun, YAO, Li and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lingxiang Mao, Affiliated Kunshan hospital of Jiangsu University, suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.