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REVIEW article

Front. Oncol.
Sec. Cancer Genetics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1464125
This article is part of the Research Topic Exploring Epigenetic Mechanisms in Cancer View all 6 articles

Transcriptomic Era of Cancers in Females: New Epigenetic Perspectives and Therapeutic Prospects

Provisionally accepted
Runhe Zhu Runhe Zhu 1Jiawei Nie Jiawei Nie 1*Jiayin Ren Jiayin Ren 1*Dongye Li Dongye Li 1*Jiawei Xu Jiawei Xu 1欣汝 于 欣汝 于 1Yingjie Ma Yingjie Ma 1*Luan Kou Luan Kou 2*
  • 1 Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2 1.Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, China, jinan, China

The final, formatted version of the article will be published soon.

    Abstract In the era of transcriptomics, the role of epigenetics in the study of cancers in females has gained increasing recognition. This article explores the impact of epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNA, on cancers in females, including breast, cervical, and ovarian cancers [1]. Our findings suggest that these epigenetic markers not only influence tumor onset, progression, and metastasis but also present novel targets for therapeutic intervention. Detailed analyses of DNA methylation patterns have revealed aberrant events in cancer cells, particularly promoter region hypermethylation, which may lead to silencing of tumor suppressor genes. Furthermore, we examined the complex roles of histone modifications and long non-coding RNAs in regulating the expression of cancer-related genes, thereby providing a scientific basis for developing targeted epigenetic therapies. Our research emphasizes the importance of understanding the functions and mechanisms of epigenetics in cancers in females to develop effective treatment strategies. Future therapeutic approaches may include drugs targeting specific epigenetic markers, which could not only improve therapeutic outcomes but also enhance patient survival and quality of life. Through these efforts, we aim to offer new perspectives and hope for the prevention, diagnosis, and treatment of cancers in females.

    Keywords: transcriptomic, Era, Cancers, females, epigenetic

    Received: 13 Jul 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Zhu, Nie, Ren, Li, Xu, 于, Ma and Kou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiawei Nie, Shandong University of Traditional Chinese Medicine, Jinan, China
    Jiayin Ren, Shandong University of Traditional Chinese Medicine, Jinan, China
    Dongye Li, Shandong University of Traditional Chinese Medicine, Jinan, China
    Yingjie Ma, Shandong University of Traditional Chinese Medicine, Jinan, China
    Luan Kou, 1.Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, China, jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.