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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1463568

Using the length of pleural tag to exclude predetermine pleural invasion by lung adenocarcinomas

Provisionally accepted
Yingdong Chen Yingdong Chen 1Qianwen Huang Qianwen Huang 1Zeyang Lin Zeyang Lin 1Xiaoxi Guo Xiaoxi Guo 1Yiting Liao Yiting Liao 2Zhe Li Zhe Li 1Anqi Li Anqi Li 1*
  • 1 Zhongshan Hospital, Xiamen University, Xiamen, China
  • 2 Maternal and Child Health care Hospital of Jimei District, xiamen, China

The final, formatted version of the article will be published soon.

    Introduction: Pleural contact is present when the underlying pathology of the pleural tag (PT) involves the pleura. This study aimed to preoperatively predict PI by lung adenocarcinomas (ACCs) with PT, exploring CT imaging parameters indicative of PT consisting of pleura and tumor invasiveness. Methods: This single-center, retrospective study included 84 consecutive patients diagnosed with solid ACCs with PT, who underwent resection at our hospital between May 2019 and July 2023. CT imaging parameters analyzed included: LPT (the length of PT), defined as the shortest distance from the tumor edge to the retracted pleura; cord-like PT. Patients were divided into PI -ve group and PI +ve group according to PI status. Regression analyses were used to determine predictive factors for PI. Results: The study evaluated 84 patients (mean age, 62.0 ± 13.8 years; 45 females) pathologically diagnosed with ACCs with PT on CT.Multivariate regression analysis identified tumor size (OR 1.18, 95% CI 1.09-1.29, p = 0.000) and ，LPT (OR 0.48, 95% CI 0.25-0.91, p = 0.03) and multiple PTs to multiple types of pleura (OR 3.58, 95% CI 1.13-11.20, p = 0.03) as independent predictors for PI. The combination of these CT features improved the predictive performance for preoperatively identifying PI, achieving high specificity and moderate accuracy. The sensitivity, specificity, and accuracy of predicting PI with only LPT < 3 mm was 26.9%, 96.9 %, 61.9%. conclusion: This study determined that large LPT is effective for excluding predetermining PI in ACCs with PT.

    Keywords: Spiral CT, Pleural invasion, Lung adenocarcinomas, Iodine uptake, Pleural tag, tumor invasiveness

    Received: 12 Jul 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Chen, Huang, Lin, Guo, Liao, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anqi Li, Zhongshan Hospital, Xiamen University, Xiamen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.