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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1463480
Establishment and validation of a nomogram model for early diagnosis of gastric cancer: A large-scale cohort study
Provisionally accepted- 1 Gansu University of Chinese Medicine, Lanzhou, Gansu, China
- 2 Gansu Provincial Hospital, Lanzhou, China
Identifying high-risk populations and diagnosing gastric cancer (GC) early remains challenging. This study aimed to establish and verify a nomogram model for the early diagnosis of GC based on conventional laboratory indicators. Methods: We performed a retrospective analysis of the clinical data of 2,770 individuals with first diagnosis of GC and 1,513 patients with benign gastric disease from January 2018 to December 2022. The cases were divided into the training set and the validation randomly ,with a ratio of 7:3. Variable screening was performed by least absolute shrinkage and selection operator (LASSO) and logistic regression analysis. A nomogram was constructed in the training set to assist in the early diagnosis of GC. Results: There were 4283 patients included in the study, with 2998 patients assigned in the training set and 1285 patients in the validation set. Through LASSO regression and logistic regression analysis, independent variables associated with GC were identified,
Keywords: gastric cancer, Nomogram model, early diagnosis, marker, Characteristic pattern
Received: 12 Jul 2024; Accepted: 12 Nov 2024.
Copyright: © 2024 Wang, Ding, Zhao, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
De hong Li, Gansu Provincial Hospital, Lanzhou, China
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