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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1462997

The value of adjusted PSAD in prostate cancer detection in the Chinese population

Provisionally accepted
Fang-Ming Wang Fang-Ming Wang *Meng Fu Meng Fu Yuzhe Tang Yuzhe Tang Jianxing Li Jianxing Li *
  • Department of Urology, Beijing Tsinghua Changgeng Hospital, Tsinghua University, Beijing, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the value of adjusted prostate-specifc antigen density (PSAD adj ) in the diagnosis of prostate cancer (PCa).The data of 410 patients who underwent transrectal ultrasound-guided prostate biopsy were retrospectively analyzed in Beijing Tsinghua Changgung Hospital between November 2014 and March 2024. All patients were divided into PCa and benign prostatic hyperplasia (BPH) groups according to pathological results.Multivariate logistic regression analyses were performed to evaluate odd ratios (ORs) of predictors for PCa occurrence. Receiver operating characteristic curves were plotted, and the area under the curve (AUC) values were used to assess and compare the diagnostic accuracies of total PSA (tPSA), free-to-total (f/t) PSA, free PSA (fPSA), PSAD, andResults: There were 166 in the PCa group and 244 in the BPH group.Multivariate analyses demonstrated that PSAD was positively correlated with the presence of PCa with the highest OR value among all PSA-related parameters (OR = 19.075, p <0.001). tPSA, fPSAD, PSAD, and PSAD adj had high accuracy in predicting PCa with AUC values of 0.633, 0.730, 0.778, and 0.780. Of note, PSAD adj had the highest AUC with a sensitivity of 63.3% and a specificity of 81.6%.Similarly, in the patients with PSA level in the gray zone, the diagnostic accuracy of PSAD adj in predicting PCa (AUC: 0.709, 95% CI: 0.616-0.802) remained better than other PSA-related markers.PSA-related markers to detect PCa and could be used for making the biopsy decision.

    Keywords: prostate cancer (PCa), Biopsy, diagnosis, Prostate-specifc antigen density (PSAD), Benign prostatic hyperplasia

    Received: 11 Jul 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Wang, Fu, Tang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fang-Ming Wang, Department of Urology, Beijing Tsinghua Changgeng Hospital, Tsinghua University, Beijing, China
    Jianxing Li, Department of Urology, Beijing Tsinghua Changgeng Hospital, Tsinghua University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.