Skip to main content

CASE REPORT article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1462930

Dramatic Impact of DNA Next Generation Sequencing Results using Specific Targeted Therapies-ALK and PIK3CA

Provisionally accepted
Stav Cullum Stav Cullum Saad Khan Saad Khan *Hlu Vang Hlu Vang Michael Glover Michael Glover Nancy Pham Nancy Pham Heather Morton Heather Morton Mobeen Rahman Mobeen Rahman Howra Alammarah Howra Alammarah
  • Stanford University, Stanford, United States

The final, formatted version of the article will be published soon.

    In the era of targeted therapies, the clinical importance and utility of next-generation sequencing (NGS) have expanded significantly. With the relative ease and financial feasibility of NGS, the use of personalized treatment strategies has the potential to revolutionize cancer care. In this case report, we explore the use of NGS in a salivary gland carcinoma (SGC) and a spindle cell neoplasm of the scalp. In the case of our patient with SGC, NGS revealed a GPHN-ALK variant which allowed consideration of off-label treatment with Alectinib, with a remarkable response in primary and metastatic foci. Similarly, use of NGS in a cutaneous neoplasm in which no definitive diagnosis could be reached by pathology and which had progressed through standard of care treatment elucidated a PIK3CA mutation for which Alpelisib was added and ultimately halted POD. We discuss the use of NGS, future projections and our recommendations further.

    Keywords: ALK inhibitor, PI3 kinase inhibitor, DNA NGS, RNA NGS, precision oncology

    Received: 10 Jul 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Cullum, Khan, Vang, Glover, Pham, Morton, Rahman and Alammarah. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Saad Khan, Stanford University, Stanford, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.