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CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1462865
This article is part of the Research Topic Therapeutic Advances in Lung Cancer and Chronic Inflammatory Lung Disease View all 16 articles

RECURRENT PNEUMOTHORACES CAUSED BY A HIGH-GRADE LUNG CARCINOMA WITH TROPHOBLASTIC DIFFERENTIATION: A CASE REPORT

Provisionally accepted
Márton Csaba Márton Csaba 1,2*Zsolt Megyesfalvi Zsolt Megyesfalvi 2,3László Báthory-Fülöp László Báthory-Fülöp 4Tamás Pintér Tamás Pintér 5László Agócs László Agócs 1,2,3Balázs Döme Balázs Döme 2,3,6Ferenc Rényi-Vámos Ferenc Rényi-Vámos 1,2,3,7Áron Kristóf Ghimessy Áron Kristóf Ghimessy 1,2
  • 1 Department of Thoracic Surgery, National Institute of Oncology (NIO), Budapest, Hungary
  • 2 Thoracic Surgery Clinic, Semmelweis University, Budapest, Hungary
  • 3 Department of Thoracic Surgery, National Koranyi Institute of TB and Pulmonology (Hungary), Budapest, Hungary
  • 4 Department of Pathology, National Institute of Oncology (NIO), Budapest, Hungary
  • 5 Department of Oncology, National Institute of Oncology (NIO), Budapest, Hungary
  • 6 Translational Thoracic Oncology Laboratory, Clinical Department of Thoracic Surgery, University Clinic for General Surgery, Medical University of Vienna, Vienna, Vienna, Austria
  • 7 National Tumor Biology Laboratory, Budapest, Hungary

The final, formatted version of the article will be published soon.

    Gestational trophoblastic neoplasms are tumors that occur during pregnancy, while non-gestational trophoblastic tumors have a similar histology but are present outside of gestation. Literature reports several cases of non-gestational trophoblastic tumors of primary pulmonary origin, which pose diagnostic challenges and are associated with a poor prognosis. This report details a case of somatic high-grade carcinoma with trophoblastic differentiation primarily manifesting in the left lung with recurrent pneumothoraces. The tumor was initially diagnosed as a poorly differentiated pleomorphic carcinoma and was treated with paclitaxel and pembrolizumab, followed by the EMA-CO/EP regimen after the detection of liver, lung, and brain metastases. Despite initial treatment responses, the disease progressed with widespread metastases and severe complications, including myelotoxicity, empyema, and subarachnoid bleeding. The disease progressed rapidly, resulting in death within two years of diagnosis, highlighting the aggressive nature of this high-grade carcinoma with trophoblastic differentiation. Non-gestational trophoblastic tumors may represent a distinct disease group with unique clinical characteristics, and genetic analysis could help identify more cases.

    Keywords: non-gestational trophoblastic tumor, Pneumothorax, VATS, wedge resection, Chest Pain, case report

    Received: 06 Sep 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Csaba, Megyesfalvi, Báthory-Fülöp, Pintér, Agócs, Döme, Rényi-Vámos and Ghimessy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Márton Csaba, Department of Thoracic Surgery, National Institute of Oncology (NIO), Budapest, Hungary

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