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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Breast Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1462850

Safety and Aesthetic Outcomes of Double Purse-string Suture Nipple Reconstruction in Early Breast Cancer Patients Undergoing Nipple Resection and Endoscopic Skin-Sparing Mastectomy with Breast Reconstruction

Provisionally accepted
Hui Dai Hui Dai 1Kawun Chung Kawun Chung 1Faqing Liang Faqing Liang 1Yanyan Xie Yanyan Xie 1Qing Zhang Qing Zhang 1Mengxue Qiu Mengxue Qiu 1Huanzuo Yang Huanzuo Yang 1Jiao Zhou Jiao Zhou 2Yu Feng Yu Feng 3Zhenggui Du Zhenggui Du 1*
  • 1 West China Hospital, Sichuan University, Chengdu, China
  • 2 The First People’s Hospital of Ziyang, Ziyang, China
  • 3 The Fourth People’s Hospital of Sichuan Province, Chengdu, China

The final, formatted version of the article will be published soon.

    Background: The current surgical methods for managing incisions after nipple excision in breast reconstruction patients are limited. However, double purse-string suture (DPS) shows promise in the treatment of nipple excision. This study aimed to investigate the safety and aesthetic outcomes of DPS nipple reconstruction in early breast cancer patients who underwent endoscopic skin-sparing mastectomy (E-SSM) and breast reconstruction. Methods: We retrospectively analyzed the clinical data of 87 early breast cancer patients with nipple excision who underwent E-SSM with breast reconstruction. According to the suture methods of nipple incision, all patients were divided into the spindle suture (SS) group, single purse-string suture (SPS) group, and DPS group, with SS and SPS groups combined as the traditional suture (TS) group. Then, we compared the groups' differences in aesthetic outcomes, surgical safety, and oncological safety. Results: A total of 87 patients with 88 breasts were enrolled in this study (SS n=17, SPS n=21, DPS n=50). Patients in the DPS group had significantly better nipple reconstruction satisfaction, Harris scale and any complications incidence than the TS group (all p <0.05). For nipple reconstruction satisfaction and any complication, the adjusted OR (95%CI) of the DPS group were 6.314(1.095-36.415) (p=0.039) and 0.124(0.018-0.863) (p=0.035) compared with the SS group. One patient in the SS group had vertebral metastases, and no recurrence, metastasis, or death has been observed in the other two groups during the follow-up period. Conclusions: DPS is an effective and safe nipple reconstruction procedure for patients undergoing E-SSM with breast reconstruction, delivering excellent aesthetic outcomes.

    Keywords: double purse-string suture, Nipple reconstruction, endoscopic skin-sparing mastectomy, Breast reconstruction, breast cancer double purse-string suture, endoscopic skinsparing mastectomy, breast cancer

    Received: 10 Jul 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Dai, Chung, Liang, Xie, Zhang, Qiu, Yang, Zhou, Feng and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhenggui Du, West China Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.