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REVIEW article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1462424
This article is part of the Research Topic Molecular and Immune Influences in the Progression of Gliomas Vol II View all 5 articles
Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection
Provisionally accepted
Wenhao Li
1,2*
Zhihao Wang
2
Siliang Chen
2
Mingrong Zuo
2
Yufan Xiang
3
Yunbo Yuan
2
Yuze He
2
Shuixn Zhang
2*
Yanhui Liu
2*- 1 Other, Chengdu, China
- 2 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 3 West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
Glioblastoma (GBM) is a highly malignant tumor of the central nervous system that remains intractable despite advancements in current tumor treatment modalities, including immunotherapy. In recent years, metabolic checkpoints (aberrant metabolic pathways underlying the immunosuppressive tumor microenvironment) have gained attention as promising therapeutic targets and sensitive biomarkers across various cancers. Here, we briefly review the existing understanding of tumor metabolic checkpoints and their implications in the biology and management of GBM. Additionally, we discuss techniques that could evaluate metabolic checkpoints of GBM non-invasively, thereby potentially facilitating neo-adjuvant treatment and dynamic surveillance.
Keywords: Glioblastoma, Metabolic checkpoints, Immunotherapy, multimodal MRI, liquid biopsy
Received: 10 Jul 2024; Accepted: 11 Nov 2024.
Copyright: © 2024 Li, Wang, Chen, Zuo, Xiang, Yuan, He, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenhao Li, Other, Chengdu, China
Shuixn Zhang, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Yanhui Liu, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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