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CASE REPORT article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1462381

Successful treatment of recurrent refractory Kaposi's sarcoma in AIDS: a case report

Provisionally accepted
Li Feng Li Feng Zheng Rongrong Zheng Rongrong *Yan Jun Yan Jun *Zhang hongdong Zhang hongdong *Liu Hong Liu Hong *Shi Jinchuan Shi Jinchuan *
  • Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Kaposi's sarcoma (KS) is a soft tissue lesion that resembles a hyperpigmented angiosarcoma and is typically associated with human herpesvirus 8 (HHV-8) infection. It is most frequently observed in immunocompromised patients, particularly those with AIDS, and is also referred to as HIV-associated Kaposi's sarcoma (AIDS-KS). The disease progresses rapidly, is challenging to manage, and has a high mortality rate. This case report presents a patient with AIDS-KS who experienced relapse after chemotherapy with anthracyclines. Subsequent chemotherapy with the same method had no significant effect. However, complete remission was achieved after the addition of a programmed cell death protein 1(PD-1) inhibitor, as confirmed by pathological biopsy. The PD-1 inhibitor was well-tolerated and had few adverse effects. It also helped to improve the immune reconstitution of the patient.

    Keywords: AIDS-related Kaposi's sarcoma, PD-1 inhibitor, Immunotherapy, Complete remission, case report

    Received: 10 Jul 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Feng, Rongrong, Jun, hongdong, Hong and Jinchuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zheng Rongrong, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, China
    Yan Jun, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, China
    Zhang hongdong, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, China
    Liu Hong, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, China
    Shi Jinchuan, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, China

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