Perceptions of physicians caring for pediatric patients with cancer in Europe: insights into the use of palliative care, its timing, and barriers to early integration

Background: Integrating pediatric palliative care (PPC) into pediatric oncology standard care is essential. Therefore, it is important to assess physicians’ knowledge and perceptions of PPC to optimize its practice.

Objective: To evaluate the knowledge, comfort levels, and perspectives of physicians regarding the timing and perceived barriers to integrating PPC into pediatric cancer care across Europe.

Design: The Assessing Doctors’ Attitudes on Palliative Treatment (ADAPT) survey, originally developed for other global regions, was culturally and contextually adapted for Europe.

Setting/Subjects: The survey was distributed via the European Society of Paediatric Oncology (SIOPE) membership listserv. Any physicians caring for children with cancer across Eastern, Southern, Central, and Northern Europe were invited to complete the survey.

Results: A total of 198 physicians from 29 European countries completed the ADAPT survey. Physicians demonstrated relative agreement with the World Health Organization’s guidance; median alignment was 83.4% (range 59.9%-94.1%). Although most respondents felt comfortable addressing physical (84.4%) and emotional (63.4%) needs, they felt less comfortable addressing spiritual needs (41.9%) and providing grief and bereavement support (48.5%). There were significant regional differences, such as physicians in Eastern and Southern Europe reporting a lack of PPC specialists, opioids, and home-based care, while those in Northern and Central Europe did not.

Conclusion: Physicians caring for children with cancer throughout Europe have a good understanding of PPC. However, misconceptions about PPC persist, requiring educational and capacity-building efforts. Additionally, the regional differences in perceived barriers must be addressed to ensure equitable access to PPC for all European children with cancer.

Introduction

The World Health Organization (WHO) has defined palliative care (PC) as “an ethical responsibility of health systems, regardless of resources.” (1) The need for PC is particularly important for pediatric populations. Evidence suggests that early integration of palliative care for children with cancer and other serious illnesses has significant benefits for patients and their families, including improved pain and symptom management, reduced caregiver and patient suffering, and better family communication (2–5).

An estimated 21 million children worldwide require pediatric palliative care (PPC) each year, with 8 million needing specialized PPC services (6). Children with cancer comprise a distinct cohort within this demographic, not only due to the symptoms and stress of having cancer, but also treatment-related toxicities they endure (7–11). In 2018, the WHO launched its Global Initiative for Childhood Cancer, with the goal of increasing pediatric cancer survival to 60% by 2030, while also alleviating suffering and improving the quality of life for children with cancer globally (12).

Unfortunately, the development and access to PPC lag far behind those of adult-oriented services (2). This discrepancy is due to multiple factors, including geography, lack of education, and a general lack of public awareness about PPC (2, 13–15). Other common barriers to integrating PPC into pediatric cancer care include physicians’ perceptions about the role and timing of PC, and the emotional relationship between the oncologist and their patients and families (16–19).

The WHO called for the strategic planning and implementation of PPC initiatives tailored to the local needs and opportunities of each region or country (2). Europe is a heterogeneous region, comprising 50 countries that communicate in 24 official languages (20, 21). Childhood cancer is the leading cause of disease related death in children older than 1 year of age in Europe with an estimated 24,000 new cases each year (22). Economic growth and development also vary greatly, from some of the world’s wealthiest countries to low- or middle-income countries (LMICs) (23–25). These disparities contribute to the variability in and accessibility to PPC services (26, 27). To address the need for PPC provision for children with cancer in Europe and reduce inequities in quality of life across regions, the Board of the European Society for Paediatric Oncology (SIOPE) recently established a PPC Working Group (7).

Furthermore, the Assessing Doctors’ Attitudes on Palliative Treatment (ADAPT) survey was developed to assess the perceptions of physicians who treat children with cancer about PPC timing and integration in their setting (28–33). In collaboration with the SIOPE PPC Working Group, we distributed this survey in Europe (ADAPT-E) to learn physicians’ perceptions about integrating PPC into standard care for children with cancer in SIOPE member countries.

Methods

IRB approval

This survey study was deemed exempt by the Office of Human Subjects Research Protections and Institutional Review Board at St. Jude Children’s Research Hospital (Memphis, TN, USA). Voluntary completion of this survey was considered consent to participate in the study.

Instrument development

A detailed description of the development of the ADAPT survey was previously published (29, 31). Briefly, ADAPT was developed according to the American Association for Public Opinion Research (AAPOR) using WHO guidance on PPC and a review of the literature on physicians’ perceptions of PC and was successfully distributed in Latin America and Eurasia (2, 33–37). For this study, the ADAPT survey went through iterative rounds of review to culturally and contextually adapt to Europe via the SIOPE PPC Working Group. The final survey consisted of 68 items: 65 were close-ended, using a 5-point Likert scale from 5 (“strongly agree”) to 1 (“strongly disagree”), or multiple-choice format, and 3 items were open-ended (Supplementary Figure S1).

Instrument distribution strategy

The ADAPT-E survey was distributed electronically in English via the Qualtrics software platform (38) and shared through the SIOP-Europe listserv from January 27 to February 27, 2023. Physicians of any specialty caring for children with cancer were included in the study. Surveys were completed anonymously, and participation was optional. No overlap in participation occurred between the Eastern European and Central Asian countries involved in the previous ADAPT study in Eurasia (29, 30).

The countries of the participating respondents were categorized into geographic regions, as informed by SIOPE and in alignment with the geographic regions delineated by the Statistics Division of the United Nations (39, 40). Although Turkey and Cyprus are in Asia, their ties to Europe justified their inclusion in the Southern Europe category for our analysis. Specifically, Cyprus is a member of the European Union, and the pediatric hematology-oncology associations of both countries are members of SIOPE.

Statistical analysis

The statistical analysis in this study mirrored that of previous ADAPT studies (29–33). Demographic data were assessed via descriptive statistics. Only fully completed surveys were included in the final analysis. Of the 68 items in the survey, 15 were categorized as in agreement or disagreement with WHO guidelines for PPC (Supplementary Table S1). Physician alignment with WHO guidelines was determined by classifying responses as correct when indicating moderate or strong agreement. An overall alignment score was then calculated for each participant, reflecting the percentage of correct answers out of a maximum possible score of 15.

In the secondary analysis focusing on multiple-choice questions, the responses originally captured on a 5-point Likert scale (ranging from “Never” to “Always”) were collapsed into three categories: “Never/Rarely”, “Sometimes”, and “Often/Always”. This reclassification was done to streamline regional comparisons, employing statistical methods such as Pearson’s χ² or Fisher’s exact test. A p-value less than 0.05 was deemed statistically significant. All data summaries and analyses were conducted using SAS software, version 9.4 (SAS Institute) (41).

Qualitative analysis

Through thematic content analysis, our study aimed to evaluate physicians’ perceptions of the components and role of PPC, their attitudes toward PPC, actions or desires they have for PPC, barriers to delivering PPC in their setting, and optimal timing of PPC initiation.

The qualitative analysis was similar to that in previous ADAPT studies (29–33). The qualitative codebook from previous studies was used, undergoing both inductive and deductive refinement. After conducting an iterative review of the free-text responses, we made minor adjustments to existing codes and added six new codes to the final ADAPT-E codebook (Supplementary Table S2). Free-text responses to two of the open-ended questions, “What does palliative care mean to you?” and “If there is a difference between when initial palliative care consultation typically occurs in your setting and what you think is ideal, why do you think this difference exists?”, were qualitatively analyzed using MAXQDA software (42).

Although most survey responses were in English, two were in Hungarian; those responses were translated to English using Google Translate and then confirmed for accuracy by a native Hungarian speaker. Each free-text response served as a unit of analysis for coding.

Results

Sample demographics

The ADAPT-E survey was completed by 198 physicians from 29 European countries (Figure 1, Table 1). Another 39 partially completed surveys were removed from analysis. The demographic data showed that most of the respondents were age 35 or older (88.9%), identified as female (67.7%), and had 11 or more years of experience as a physician (85.9%). The most common specialty was pediatric hematology-oncology (74.2%), followed by PPC (9.6%) and general pediatrics (7.1%). Most (86.4%) respondents reported access to PC consultation services. Within this group, the majority (99%) had access to a PC physician and an interdisciplinary PPC team (76%), including psychologists (76%) and nurses (85%). Furthermore, 122 (61.6%) respondents had prior training in PC: 37 (30.3%) completed a certificate course, and 14 (11.5%) completed a dedicated residency or fellowship (Supplementary Table S7). Notably, 190 (96.0%) respondents reported having at least 1 patient die in the previous year.

Figure 1

Figure 1. Geographic Distribution of ADAPT Survey Participation by Physicians Caring for Pediatric Patients with Cancer Across European Regions. A map of the European countries represented by the respondents of the survey is shown in the figure. Country colors are associated with the different regions: red is Northern Europe, yellow is Central Europe, green is Eastern Europe, and blue is Southern Europe.

Table 1

Table 1. Demographic characteristics of respondents caring for pediatric patients with cancer to the assessing doctors’ attitudes on palliative treatment survey in Europe.

Alignment with WHO guidelines

Physicians demonstrated relative alignment with WHO guidance for PPC, with a median alignment of 83.4% (range 58.7%-94.4%). Most (94.4%) respondents correctly disagreed with the statement that “children with cancer who receive palliative care die earlier than those who do not”; 91.4% agreed that “palliative care can be integrated with disease-directed therapy,” and 90.7% agreed that “involvement of palliative care during cancer therapy gives greater attention to quality of life and symptom management (e.g. pain, constipation, dyspnea, fatigue).” The three areas of lowest alignment with WHO guidelines included beliefs that “early consultation with palliative care causes increased parental burden and anxiety” (58.7%), “it is difficult to know when a patient with cancer would most benefit from meeting the palliative care team” (60.2%), and “palliative care for children with cancer can be delivered by health care workers of all disciplines, not only by palliative care specialists” (64.8%) (Supplementary Table S3).

Pediatric palliative care in practice and its components

Although some broadly defined PPC as “accompanying children and their families on a daily basis in order to establish life projects and projects before death, when it is inevitable, in the best possible conditions,” others focused on specific components, such as “psychological support to parents, relatives, patient itself.” A unique theme that emerged from our analysis was the frequent use of the term “holistic”; many respondents described PPC as a “holistic approach for the care of children, families, and health workers.” Respondents provided additional insights into their perceptions of PPC through free-text responses (Supplementary Table S4).

Physician comfort

When analyzing physician confidence in evaluating and treating the needs of pediatric patients with serious incurable illnesses, most respondents reported feeling comfortable with addressing the patient’s physical needs (84.4%), as well as the patient and their family’s emotional needs (63.6%). Physicians felt less comfortable assessing and treating spiritual needs (41.9%) or providing grief and bereavement care to the families of patients who die (48.5%). Additionally, 25.3% of respondents reported feeling burdened by their inability to control the suffering of patients at the end of life (EoL) at least some of the time (Table 2).

Table 2

Table 2. Physician comfort in addressing the needs of their pediatric patients with cancer in Europe.

Ideal vs. actual timing of pediatric palliative care

While 34% of physicians believe that, ideally, PPC should be offered at the time of diagnosis for all patients, only 5% said that occurs in their setting (p <0.001). This disparity extends to patients at high risk of relapse or progression: 57% of physicians believe PPC should be integrated at the time of diagnosis, though only 33% have witnessed it in their setting (p <0.001). Conversely, most (70%) stated that PC is integrated in their setting when curative treatments are no longer available, but only 45% believe that timing is ideal (p <0.001). Also, 47% of physicians reported that PC is integrated into patient care at the EoL, but only 32% believe that is the ideal timing (Figure 2).

Figure 2

Figure 2. Ideal vs. Actual Timing of Initial Palliative Care Consultation for Pediatric Patients with Cancer. A bar graph showing the significant disparity between the ideal (light blue color) and actual (purple color) timing of the initial pediatric palliative care consultation, depending on specific events. *P <0.05; **P >0.001. Results of 198 physician respondents to the multiple-choice questions asking when initial palliative care consultation for a child with cancer typically occurs in their setting and when they believe is the ideal time it should occur. Participants were asked to “choose all that apply”.

In the free-text responses, physicians elaborated on why the actual and ideal timing for PC integration differed. For example, “it still feels more natural to start consulting the palliative team in case curative options are limited.” Another shared that they “try to find a reason to introduce patients at high risk of relapse to the palliative care team at first diagnosis, for example, if there are troublesome symptoms…” and “… would always involve them for patients needing support in symptom control irrespective of prognosis” (Supplementary Table S4).

Barriers to pediatric palliative care integration

Of the 12 perceived barriers to early integration of PPC included in the survey, eight were indicated as somewhat or extremely important by at least 50% of respondents (Table 3). The most frequently perceived barriers included: physician discomfort (82.3%), family resistance (72.2%), limited physician knowledge (71.2%), physician desire to maintain hope (71.2%), and uncertainty about patient prognosis (59.1%). Conversely, the least frequently reported barriers were limited access to opioids (16.7%) and the cost of palliative care education and treatment (17.2%).

Table 3

Table 3. Barriers to the early integration of palliative care for pediatric patients with cancer in Europe.

Physicians expanded on the perceived barriers in their settings with their free-text responses. For example, “… there is still a lack of deep knowledge about pediatric palliative care on the part of other health care providers who take care of the child with cancer. Pediatric palliative care involvement is still unknowingly experienced as a failure by oncologists,” and how some physicians still have a “misconception that palliative care is the same as end-of-life care.” Some respondents also mentioned barriers beyond their control, such as the lack of access, “Palliative care is not developed, so it is usually not available or it is ‘used’ just for pain management,” or how PPC integration, “… depends on the resource in the territory” (Supplementary Table S4).

Regional analysis

We extended our analysis to compare responses across four European regions: Northern, Southern, Central, and Eastern (Supplementary Table S5). While the alignment of physicians’ answers with WHO guidelines across regions was similar (78.1% to 84.2% Supplementary Table S6) significant regional differences in several barriers to PPC integration were identified. These included limited physician knowledge of the role of PC (p = 0.03), lack of access to home-based services (p <0.01), limited access to opioids (p = 0.01), and lack of access to PC specialists or services (p <0.01) (Table 4). While 25.0% of physicians in Central Europe considered the lack of home-based services an important barrier, 76.5% in Eastern Europe and 69.2% in Southern Europe felt this was an important impediment to early integration of palliative care. Additionally, only 7.1% of Central European physicians reported lack of access to opioids as an important barrier, compared to 26.5% in Eastern Europe and 20.5% in Southern Europe. Lastly, 32.1% of physicians in Central Europe stated that the lack of access to PC specialists or services was an important barrier, which was significantly fewer than 73.5% in Eastern Europe and 60.3% in Southern Europe (Table 4).

Table 4

Table 4. Important barriers to the early integration of palliative care for pediatric patients with cancer by European Region.

Discussion

Palliative care is considered an essential part of care for serious or life-threatening health conditions. By relieving or preventing symptoms and mitigating the adverse effects of treatment, PC enhances patient’s adherence to their treatment regimens (2). Furthermore, the early integration of PC for patients with life-threatening conditions is an ethical responsibility of clinicians (2). Therefore, understanding physicians’ perceptions of PC is imperative for improving its delivery and implementation.

When we compared our findings with results from previous ADAPT studies, our cohort’s alignment with WHO guidelines was 83.4%, matching the LA cohort (83%) and surpassing the Eurasian cohort (70%) (29, 31). However, further education is warranted, as evidenced by the 40% of our respondents who erroneously stated that “early consultation with PPC causes increased parental burden and anxiety,” and “it is difficult to know when a patient with cancer would most benefit from meeting the PC team.” These findings will help tailor PPC curricula for European physicians to address these misconceptions. Similar initiatives have been successful in Eastern Europe and Central Asia (43).

Additionally, physician knowledge of PPC does not automatically translate into proficient clinical skills or comfort in providing PPC (37). Therefore, we evaluated physicians’ comfort level in addressing patient needs. In our cohort, European physicians were more comfortable addressing the physical and emotional needs of their patients than the LA and Eurasian physicians (29, 31). However, fewer than half were comfortable addressing patients’ spiritual needs or providing grief and bereavement support, which is similar to findings from Eurasia (29). Moreover, family members often feel abandoned by the medical system after their child dies (44–46). Hence, further physician training and education on supporting families after their child’s death is needed. Teaching physicians about grief and bereavement and giving them practical opportunities to interact with and learn from bereaved parents could help alleviate this discomfort (46–48).

Our assessment of perceived barriers to early integration of PPC for pediatric oncology patients revealed three key barriers: physician discomfort about PPC, family resistance, and physician desire to maintain hope. These findings are similar to those from a recent study on PPC availability in pediatric oncology centers across Europe, which identified parental perception, late referrals, and healthcare professionals’ lack of awareness as common barriers (49). These barriers were also identified in the Eurasian and LA ADAPT survey results (30, 32). Despite significant cultural, resource, and linguistic differences across settings, barriers to PPC integration for children with cancer appear to be similar worldwide. Therefore, a global intervention may be adaptable to various contexts and settings. Notably, the access to PC providers, as reported by nearly all respondents in our survey, was much greater than what was reported in LA and Eurasia (29, 31). This discrepancy underscores that access to PC professionals does not fully address the barriers to PPC delivery. There is a global need for concerted efforts to foster an understanding of the essential role and necessity of PPC.

One of the barriers identified in other studies includes the resistance of oncologists to PPC integration due to the strong emotional relationship between the oncologist and their patients and families (18, 19). Concerted education efforts for oncologists and other healthcare professionals caring for children with cancer are needed to increase their comfort in caring for and discussing palliative care with their patients. This provides an opportunity to highlight the unique features of and differences between primary versus specialty palliative care. This training is essential for these professionals to understand and feel comfortable with the elements of primary palliative care, while recognizing when and how specialty palliative care can be integrated into their patients’ treatment (50).

Certain barriers vary by region. For instance, the lack of home-based services was the most common barrier in LA and Eurasia, but less so in Europe. The cost of PC consultation and treatment was identified as a barrier by most physicians in LA and Eurasia, but only by 17% of physicians in Europe (30, 32). These differences support tailoring PC efforts to local needs and account for the unique healthcare systems and cultural contexts in different regions around the world.

European countries exhibit significant diversity, particularly in terms of economic status. Despite all being classified as ‘high-income’ by the World Bank—meaning their gross national income (GNI) per capita exceeds $13,846 USD (51) —the disparities are stark, exemplified by comparing Romania’s GNI per capita of $14,160 to Switzerland’s $90,600 (52). Moreover, we found significant differences in access to PC consultation, home-based services, and opioids across European regions. Southern and Eastern Europe consistently reported greater challenges in these areas, aligning more closely with the patterns seen in Eurasia and LA. This finding highlights the need for creating more equitable access to PPC knowledge, medications, and services (26, 27).

Study limitations

This study has several limitations. First, the survey was distributed only in English, which may have limited some responses. However, most physicians in Europe do speak English. Second, accurately measuring perceptions is a challenge. Hence the importance of both the quantitative responses regarding perceived barriers and the open-ended free text responses to better understand context. Third, many responses emphasized PPC as a holistic approach to care, but our study specifically focused on the perceptions of physicians. This highlights the need for further research on the perceptions of other healthcare members (e.g. nurses, psychologists, social workers) on the multidisciplinary team about PPC. Fourth, data privacy laws made it impossible to calculate an accurate response rate, which may overestimate the significance of the conclusions drawn. Fifth, distributing the survey through a listserv might have decreased the number of responses due to survey fatigue among members. Lastly, due to the small number of respondents per country, we could not conduct a country-level analysis of the perceptions and barriers.

Conclusion

This study highlights that throughout Europe, physicians who care for children with cancer understand PPC and are comfortable with the physical and emotional aspects of their patients’ care. Nonetheless, challenges persist, including misconceptions about PC and unease in addressing spiritual needs and providing grief and bereavement support. These areas call for dedicated, concerted educational initiatives and capacity-building efforts. Moreover, despite notable similarities in the barriers identified across regions, considerable differences exist, particularly concerning the lack of PPC specialists, access to opioids, and home-based services. These disparities underscore the need for focused actions to ensure that all children have equitable access to PPC resources regardless of location. The insights gained from this study will inform strategies to improve the quality of life for children with cancer across Europe.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding author.

Ethics statement

This research was reviewed and approved by the Office of Human Subjects Research Protections Institutional Review Board at St. Jude Children’s Research Hospital. Approval No. 012647: Exempt from the need of formal informed consent.

Author contributions

IB-C: Writing – original draft, Writing – review & editing, Data curation, Formal analysis. AL: Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing. BE: Writing – review & editing. GJ: Data curation, Formal analysis, Writing – review & editing, Software, Validation, Visualization. MA: Writing – review & editing. UL: Writing – review & editing. GK: Writing – review & editing. KS: Writing – review & editing. FC: Writing – review & editing. KK: Writing – review & editing. MD: Data curation, Formal analysis, Writing – review & editing, Software, Validation, Visualization. JB: Writing – review & editing. AA: Writing – review & editing. MM: Funding acquisition, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing, Project administration, Resources.

Funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the American Lebanese Syrian Associated Charities (ALSAC).

Acknowledgments

We appreciate the SIOPE office for distributing the survey and the respondents who participated in the study.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fonc.2024.1461668/full#supplementary-material

References

1. World Health Organization. Strengthening of palliative care as a component of comprehensive care throughout the life course. Sixty-seventh World Health Assembly, Geneva, 19–24 May 2014. Available online at: http://apps.who.int/gb/ebwha/pdf_files/WHA67/A67_R19-en.pdf (Accessed 23 June 2022).

Google Scholar

2. World Health Organization. Integrating Palliative Care and Symptom Relief Into Paediatrics: A WHO Guide for Health-Care Planners, Implementers And Managers. Geneva: World Health Organization (2018).

Google Scholar

3. Wolfe J, Hammel JF, Edwards KE, Duncan J, Comeau M, Breyer J, et al. Easing of suffering in children with cancer at the end of life: is care changing? J Clin Oncol. (2008) 26(10):1717–23. doi: 10.1200/JCO.2007.14.0277

PubMed Abstract | Crossref Full Text | Google Scholar

4. Groh G, Borasio GD, Nickolay C, Bender HU, von Luttichau I, Fuhrer M. Specialized pediatric palliative home care: a prospective evaluation. J Palliat Med. (2013) 16:1588–94. doi: 10.1089/jpm.2013.0129

PubMed Abstract | Crossref Full Text | Google Scholar

5. Groh G, Vyhnalek B, Feddersen B, Fuhrer M, Borasio GD. Effectiveness of a specialized outpatient palliative care service as experienced by patients and caregivers. J Palliat Med. (2013) 16:848–56. doi: 10.1089/jpm.2012.0491

PubMed Abstract | Crossref Full Text | Google Scholar

6. Connor SR, Downing J, Marston J. Estimating the global need for palliative care for children: A cross-sectional analysis. J Pain Symptom Manage. (2017) 53:171–7. doi: 10.1016/j.jpainsymman.2016.08.020

PubMed Abstract | Crossref Full Text | Google Scholar

7. Lacerda A, Martínez MA, Dumont B, Leiss U, Kokkinou G, Scheinemann K, et al. Embracing paediatric palliative care in paediatric oncology from diagnosis onwards. Pediatr Blood Cancer. (2023) 70:e30561. doi: 10.1002/pbc.v70.10

PubMed Abstract | Crossref Full Text | Google Scholar

8. Snaman J, McCarthy S, Wiener L, Wolfe J. Pediatric palliative care in oncology. J Clin Oncol. (2020) 38:954–62. doi: 10.1200/JCO.18.02331

PubMed Abstract | Crossref Full Text | Google Scholar

9. Requena ML, Avery M, Feraco AM, Uzal LG, Wolfe J, Dussel V. Normalization of symptoms in advanced child cancer: the pediquest-response case study. J Pain Symptom Manage. (2022) 63:548–62. doi: 10.1016/j.jpainsymman.2021.12.009

PubMed Abstract | Crossref Full Text | Google Scholar

10. Hill DL, Walter JK, Szymczak JE, DiDomenico C, Parikh S, Feudtner C. Seven types of uncertainty when clinicians care for pediatric patients with advanced cancer. J Pain Symptom Manage. (2020) 59:86–94. doi: 10.1016/j.jpainsymman.2019.08.010

PubMed Abstract | Crossref Full Text | Google Scholar

11. Ullrich CK, Lehmann L, London WB, Guo D, Sridharan M, Koch R, et al. End-of-life care patterns associated with pediatric palliative care among children who underwent hematopoietic stem cell transplant. Biol Blood Marrow Transplant. (2016) 22(6):1049–55. doi: 10.1016/j.bbmt.2016.02.012

PubMed Abstract | Crossref Full Text | Google Scholar

12. WHO. Cancer in children . Geneva. Available online at: https://www.who.int/news-room/fact-sheets/detail/cancer-in-children (Accessed September 12, 2023).

Google Scholar

13. Connor SR, Sepulveda Bermedo MC. Global Atlas of Palliative Care at the End of Life. London, UK: Worldwide Palliative Care Alliance (2020).

Google Scholar

14. Caruso Brown AE, Howard SC, Baker JN, Ribeiro RC, Lam CG. Reported availability and gaps of paediatric palliative care in low- and middle-income countries: a systematic review of published data. J Pall Med. (2014) 17:1–14. doi: 10.1089/jpm.2014.0095

Crossref Full Text | Google Scholar

15. Downing J, Powell RA, Marston J, Huwa C, Chandra L, Garchakova A, et al. Children’s palliative care in low-and middle-income countries. Arch Dis Child. (2015) 101:85–90. doi: 10.1136/archdischild-2015-308307

PubMed Abstract | Crossref Full Text | Google Scholar

16. Dalberg T, McNinch NL, Friebert S. Perceptions of barriers and facilitators to early integration of pediatric palliative care: a national survey of pediatric oncology providers. Pediatr Blood Cancer. (2018) 65:e26996. doi: 10.1002/pbc.26996

PubMed Abstract | Crossref Full Text | Google Scholar

17. Lynch T, Clark D, Centeno C, Rocafort J, Flores LA, Greenwood A, et al. Barriers to the development of palliative care in the countries of Central and Eastern Europe and the Commonwealth of Independent States. J Pain Symptom Manage. (2009) 37(3):305–15. doi: 10.1016/j.jpainsymman.2008.03.011

PubMed Abstract | Crossref Full Text | Google Scholar

18. Thompson LA, Knapp C, Madden V, Shenkman E. Pediatricians’ perceptions of and preferred timing for pediatric palliative care. Pediatrics. (2009) 123:e777–82. doi: 10.1542/peds.2008-2721

PubMed Abstract | Crossref Full Text | Google Scholar

19. Ceballos-Yáñez D, Astudillo PP, Eugenin-Soto MI. Facilitators and barriers perceptions to early referral to pediatric palliative care perceived. Andes Pediatr. (2023) 94:307–15. doi: 10.32641/andespediatr.v94i3.4382

PubMed Abstract | Crossref Full Text | Google Scholar

20. United Nations. Regional groups of Member States. Available online at: https://www.un.org/dgacm/en/content/regional-groups (Accessed November 13, 2023).

Google Scholar

21. European Union. Languages. Available online at: https://european-union.europa.eu/principles-countries-history/languages_en (Accessed November 13, 2023).

Google Scholar

22. International Agency for Research on Cancer. Global cancer observatory: cancer today. Lyon, France: International Agency for Research on Cancer (2023). Available at: https://gco.iarc.fr/today/en/dataviz/pie?types=0&mode=cancer&group_populations=1&sort_by=value1&populations=908&age_end=3.

Google Scholar

23. European Central Bank. Economic diversity. Available online at: https://www.ecb.europa.eu/mopo/eaec/diversity/html/index.en.html (Accessed November 13, 2023).

Google Scholar

24. World Bank. World Bank country and lending groups(2023). Available online at: https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups (Accessed November 15, 2023).

Google Scholar

25. World Bank. World Bank open data. Available online at: https://data.worldbank.org/ (Accessed November 15, 2023).

Google Scholar

26. Arias-Casais N, Garralda E, Pons JJ, Marston J, Chambers L, Downing J, et al. Mapping pediatric palliative care development in the WHO-European region: children living in low-to-middle-income countries are less likely to access it. J Pain Symptom Manage. (2020) 60:746–53. doi: 10.1016/j.jpainsymman.2020.04.028

PubMed Abstract | Crossref Full Text | Google Scholar

27. Arias-Casais N, Garralda E, Rhee J. EAPC atlas of palliative care in Europe. Romania. (2019) 122:0–6. Available online at: https://www.hospiz.at/wordpress/wp-content/uploads/2019/07/EAPC-Atlas-2019-final-web.pdf.

Google Scholar

28. St Jude Children’s Research Hospital. St Jude Global: taking St Jude to the world. Available online at: https://www.stjude.org/global.html (Accessed August 4, 2023).

Google Scholar

29. Ehrlich BS, Movsisyan N, Batmunkh T, Kumirova E, Borisevich MV, Kirgizov K, et al. A multicountry assessment in Eurasia: alignment of physician perspectives on palliative care integration in pediatric oncology with World Health Organization guidelines. Cancer. (2020) 126(16):3777–87. doi: 10.1002/cncr.v126.16

PubMed Abstract | Crossref Full Text | Google Scholar

30. Ehrlich BS, Movsisyan N, Batmunkh T, Kumirova E, Borisevich MV, Kirgizov K, et al. Barriers to the early integration of palliative care in pediatric oncology in 11 Eurasian countries. Cancer. (2020) 126(22):4984–93. doi: 10.1002/cncr.v126.22

PubMed Abstract | Crossref Full Text | Google Scholar

31. McNeil MJ, Ehrlich BS, Wang H, Vedaraju Y, Bustamante M, Dussel V, et al. Physician perceptions of palliative care for children with cancer in Latin America. JAMA Netw Open. (2022) 5(3):e221245. doi: 10.1001/jamanetworkopen.2022.1245

PubMed Abstract | Crossref Full Text | Google Scholar

32. McNeil MJ, Ehrlich BS, Wang H, Bustamante M, Dussel V, Friedrich P, et al. Ideal vs actual timing of palliative care integration for children with cancer in Latin America. JAMA Netw Open. (2023) 6(1):e2251496. doi: 10.1001/jamanetworkopen.2022.51496

PubMed Abstract | Crossref Full Text | Google Scholar

33. McNeil MJ, Godfrey A, Loggetto P, de Oliveira Junior A, Job G, Boldrini E, et al. Physician perceptions of and barriers to pediatric palliative care for children with cancer in Brazil. JCO Glob Oncol. (2023) 9:e2300057. doi: 10.1200/GO.23.00057

PubMed Abstract | Crossref Full Text | Google Scholar

34. Dalberg T, Jacob-Files E, Carney PA, Meyrowitz J, Fromme EK, Thomas G. Pediatric oncology providers’ perceptions of barriers and facilitators to early integration of pediatric palliative care. Pediatr Blood Cancer. (2013) 60:1875–81. doi: 10.1002/pbc.24673

PubMed Abstract | Crossref Full Text | Google Scholar

35. Pifer PM, Farrugia MK, Mattes MD. Comparative analysis of the views of oncologic subspecialists and palliative/supportive care physicians regarding advanced care planning and end-of-life care. Am J Hosp Palliat Care. (2018) 35:1287–91. doi: 10.1177/1049909118763592

PubMed Abstract | Crossref Full Text | Google Scholar

36. Sanchez Varela AM, Johnson LM, Kane JR, Kasow KA, Quintana Y, Coan A, et al. Ethical decision making about end-of-life care issues by pediatric oncologists in economically diverse settings. J Pediatr Hematol Oncol. (2015) 37:257–63. doi: 10.1097/MPH.0000000000000271

PubMed Abstract | Crossref Full Text | Google Scholar

37. Friedrichsdorf SJ, Remke S, Hauser J, Foster L, Postier A, Kolste A, et al. Development of a pediatric palliative care curriculum and dissemination model: Education in Palliative and End-of-Life Care (EPEC) Pediatrics. J Pain Symptom Manage. (2019) 58:707–720.e3. doi: 10.1016/j.jpainsymman.2019.06.008

PubMed Abstract | Crossref Full Text | Google Scholar

38. Qualtrics. (2005). Seattle, WA: Qualtrics. Available online at: https://www.qualtrics.com/ (accessed June 23, 2022).

Google Scholar

39. United Nations. Standard country or area codes for statistical use. Available online at: https://unstats.un.org/unsd/methodology/m49/ (Accessed November 13, 2023).

Google Scholar

40. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, et al. International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol. (2017) 18(6):719–31. doi: 10.1016/S1470-2045(17)30186-9

PubMed Abstract | Crossref Full Text | Google Scholar

41. SAS Institute Inc. SAS/STAT 13.1 User’s Guide. Cary, NC: SAS Institute Inc (2013).

Google Scholar

42. Schönfelder W. CAQDAS and qualitative syllogism logic—NVivo 8 and MAXQDA 10 compared. Forum Qual Soc Res. (2011) 12:21. Available online at: https://www.ssoar.info/ssoar/handle/document/21660.

Google Scholar

43. McNeil MJ, Ehrlich B, Yakimkova T, Wang H, Mishkova V, Bezler Z, et al. Regional adaptation of the education in palliative and end-of-life Care Pediatrics (EPEC-Pediatrics) curriculum in Eurasia. Cancer Med. (2013) 12(3):3657–69. doi: 10.1002/cam4.5213

Crossref Full Text | Google Scholar

44. Stevenson M, Achille M, Liben S, Proulx M-C, Humbert N, Petti A, et al. Understanding how bereaved parents cope with their grief to inform the services provided to them. Qual Health Res. (2017) 27:649–64. doi: 10.1177/1049732315622189

PubMed Abstract | Crossref Full Text | Google Scholar

45. Rosenberg AR, Baker KS, Syrjala K, Wolfe J. Systematic review of psychosocial morbidities among bereaved parents of children with cancer. Pediatr Blood Cancer. (2011) 58:503–12.

PubMed Abstract | Google Scholar

46. Snaman JM, Kaye EC, Torres C, Gibson DV, Baker JN. Helping parents live with the hole in their heart: The role of health care providers and institutions in the bereaved parents’ grief journeys. Cancer. (2016) 122:2757–65. doi: 10.1002/cncr.v122.17

PubMed Abstract | Crossref Full Text | Google Scholar

47. Snaman JM, Kaye EC, Levine DR, Cochran B, Wilcox R, Sparrow CK, et al. Empowering bereaved parents through the development of a comprehensive bereavement program. J Pain Symptom Manage. (2017) 53:767–75. doi: 10.1016/j.jpainsymman.2016.10.359

PubMed Abstract | Crossref Full Text | Google Scholar

48. Spraker-Perlman HL, Aglio T, Kaye EC, Levine D, Barnett B, Berry Carter K, et al. Leveraging grief: involving bereaved parents in pediatric palliative oncology program planning and development. Children (Basel). (2021) 8:472. doi: 10.3390/children8060472

PubMed Abstract | Crossref Full Text | Google Scholar

49. Pedraza EC, Raguindin PF, Hendriks MJ, Vokinger AK, De Clercq E, Ruesch K, et al. Palliative care services in paediatric oncology centers across Europe: A cross-sectional survey. EJC Paediatr Oncol. (2023) 2:125.

Google Scholar

50. Hui D, Bruera E. Integrating palliative care into the trajectory of cancer care. Nat Rev Clin Oncol. (2016) 13:159–71. doi: 10.1038/nrclinonc.2015.201

PubMed Abstract | Crossref Full Text | Google Scholar

51. World Bank. World Bank Country and Lending Groups [Internet]. (2023). Available online at: https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups (Accessed November 15, 2023).

Google Scholar

52. World Bank. World Bank Open Data [Internet]. Available online at: https://data.worldbank.org/ (accessed November 15, 2023).

Google Scholar