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BRIEF RESEARCH REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1461092
This article is part of the Research Topic Management of Rare Oncological Cases View all 37 articles
Uterine Inflammatory myofibroblastic tumor: A retrospective analysis
Provisionally accepted- West China Second University Hospital, Sichuan University, Chengdu, China
Uterine inflammatory myofibroblastic tumor (UIMT) is a rare tumor of the female reproductive tract with uncertain malignant potential.Previous case series reports have limited our understanding of its diagnosis and treatment. Therefore, we conducted a retrospective analysis of patient files at West China Second Hospital, Sichuan University to contribute valuable clinical insights to future treatment strategies for this disease. Method: We comprehensively reviewed patient files of individuals diagnosed with UIMT from January 1st, 2013 to May 1st, 2023. Results: We included twenty-seven cases of uterine inflammatory myofibroblastic tumor in our study. Of these, 51.85% (14 cases) were diagnosed with abnormal uterine bleeding, 2 cases had dysmenorrhea, and 12 were unexpectedly diagnosed with suspected uterine fibroids. Ten cases performed total hysterectomy, and 17 cases underwent lesion resection. The positive rate of anaplastic lymphoma kinase (ALK) immunohistochemistry reached 96.3%. After a median of 8 months follow-up time, all patients were disease-free and had survived. Conclusion: Uterine inflammatory myofibroblastic tumor is easily misdiagnosed, making its diagnosis challenging. Histological features, immunohistochemical results, and molecular confirmation using fluorescence in situ hybridization (FISH) or Next-generation sequencing should be used to confirm the diagnosis. Positive ALK immunohistochemistry, ALK rearrangement, ALK fusion are helpful in diagnosis and ALK inhibitor therapy. Total hysterectomy is often performed for women who do not require fertility, while lesion resection and close follow-up may be considered for those who require fertility preservation.
Keywords: inflammatory myofibroblastic tumor, Anaplastic lymphoma kinase, Uterine leiomyoma, diagnosis, Uterus, retrospective analysis
Received: 07 Jul 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Bai, Han, Zheng and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yali Chen, West China Second University Hospital, Sichuan University, Chengdu, China
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