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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1460467
No genetic causal relationship between acne and prostate cancer through Mendelian randomization combined with meta-analysis
Provisionally accepted- Second Hospital of Hebei Medical University, Shijiazhuang, China
Background: Previous observational studies regarding relationship between acne and prostate cancer have reported inconsistent results. Due to that such studies are prone to biases, we conducted this Mendelian randomization analysis to better explore the causal association between acne and prostate cancer.The genetic data for assessing acne were acquired from the largest genomewide association study(GWAS) of acne by far and the genetic data for assessing prostate cancer were acquired from FinnGen consortium, UK Biobank, European Bioinformatics Institute and IEU OpenGWAS project. We performed two-sample Mendelian randomization(MR) analyses utilizing data from these GWAS followed by a meta-analysis to give an overall evaluation. The primary MR methods used included inverse variance weighted, MR-egger and weighted median. Leave-one-out sensitivity tests, Cochran's Q tests, and MR-egger intercept tests were used to bolster the robustness of MR results.Results: Through Mendelian randomization combined with meta-analysis, our study found no genetic causal relationship between acne and prostate cancer(P=0.378; OR=0.985;95%CI 0.954-1.018) .Sensitivity tests ensure robustness of this result.Acne shouldn't be considered as a morbidity hazard factor for prostate cancer.
Keywords: prostate cancer, Mendelian Randomization Analysis, Meta-analysis, morbidity hazard factor, Acne
Received: 06 Jul 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 He, Wang, Wang, Wang, Qi, jia, Zhang, Meng, Yan, Guo and Qu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Changbao Qu, Second Hospital of Hebei Medical University, Shijiazhuang, China
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