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CASE REPORT article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1459470

Renal metastasis of gastric cancer caused acute kidney injury which resulted with hemodialysis: case report and literature review

Provisionally accepted
Ivo Dilber Ivo Dilber 1*Stjepko Pleština Stjepko Pleština 2Domina Kekez Domina Kekez 2Ivana V. Šokec Ivana V. Šokec 3Marijana Coric Marijana Coric 2Juraj Prejac Juraj Prejac 2
  • 1 General Hospital Zadar, Zadar, Croatia
  • 2 University Hospital Centre Zagreb, Zagreb, Croatia
  • 3 Dr. Tomislav Bardek General Hospital, Koprivnica, Koprivnica-Krizevci, Croatia

The final, formatted version of the article will be published soon.

    Gastric cancer ranks fourth among the most commonly diagnosed cancers, with over a million new cases diagnosed worldwide each year. Acute and chronic kidney damage are common in patients with malignant diseases and are associated with increased risk of complications and mortality. Rarely, acute renal insufficiency may result from bilateral infiltration of renal parenchyma by tumor cells from another organ. We present a case of a patient with clinical suspected gastric cancer and metastases to the kidneys leading to acute renal failure requiring hemodialysis. Despite gastric biopsies, no tumor cells were found, while histopathological examination of enlarged intra-abdominal lymph node biopsy material confirmed adenocarcinoma of signet ring cell originating from the digestive system. Stomach cancer was identified as the most likely primary site after the kidney biopsy was performed. To the best of our knowledge, no case of gastric cancer leading to kidney metastases and acute renal failure requiring renal replacement therapy was yet described. Multidisciplinary collaboration among oncologists, urologists, radiologists, pathologists, and nephrologists is essential for the optimal treatment outcome of these patients, who generally have a poor prognosis.

    Keywords: gastric cancer, Renal metastasis, acute renal insufficiency, Kidney biopsy, hemodialysis

    Received: 04 Jul 2024; Accepted: 05 Aug 2024.

    Copyright: © 2024 Dilber, Pleština, Kekez, Šokec, Coric and Prejac. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ivo Dilber, General Hospital Zadar, Zadar, Croatia

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