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REVIEW article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1459313

The role and mechanism of compressive stress in tumor

Provisionally accepted
Min Tan Min Tan Bingqi Song Bingqi Song *Xinbin Zhao Xinbin Zhao *Jing Du Jing Du *
  • Beihang University, Beijing, China

The final, formatted version of the article will be published soon.

    Recent research has revealed the important role of mechanical forces in the initiation and progression of tumors. The interplay between mechanical and biochemical cues affects the function and behavior of tumor cells during the development of solid tumors, especially their metastatic potential. The compression force generated by excessive cell proliferation and the tumor microenvironment widely regulates the progression of solid tumor disease. Tumor cells can sense alterations in compressive stress through diverse mechanosensitive components and adapt their mechanical characteristics accordingly to adapt to environmental changes. Here, we summarize the current role of compressive stress in regulating tumor behavior and its biophysical mechanism from the mechanobiological direction

    Keywords: Compressive stress, metastasis, mechanical force, Cell extrusion, Tumor Microenvironment

    Received: 04 Jul 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Tan, Song, Zhao and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bingqi Song, Beihang University, Beijing, China
    Xinbin Zhao, Beihang University, Beijing, China
    Jing Du, Beihang University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.