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REVIEW article

Front. Oncol.
Sec. Cardio-Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1453090

Common Biological Processes and Mutual Crosstalk Mechanisms Between Cardiovascular Disease and Cancer

Provisionally accepted
Hanwei Gao Hanwei Gao 1Zhongyu Chen Zhongyu Chen 1,2Yutong Yao Yutong Yao 1,2Yuquan He Yuquan He 1,2*Xin Hu Xin Hu 1,2*
  • 1 Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
  • 2 CJUH-JLU-China iGEM Team, Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Cancer and cardiovascular disease (CVD) are leading causes of mortality and thus represent major health challenges worldwide. Clinical data suggest that cancer patients have an increased likelihood of developing cardiovascular disease, while epidemiologic studies have shown that patients with cardiovascular disease are also more likely to develop cancer. These observations underscore the increasing importance of studies exploring the mechanisms underlying the interaction between the two diseases. We review their common physiological processes and potential pathophysiological links.We explore the effects of chronic inflammation, oxidative stress, and disorders of fatty acid metabolism in CVD and cancer, and also provide insights into how cancer and its treatments affect heart health, as well as present recent advances in reverse cardio-oncology using a new classification approach.

    Keywords: Cancer, Cardio-oncology, cardiovascular disease, cardiovascular toxicity, reverse cardio-oncology

    Received: 22 Jun 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Gao, Chen, Yao, He and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuquan He, Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
    Xin Hu, Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.