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REVIEW article
Front. Oncol.
Sec. Pediatric Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1452661
YB1 and Its Role in Osteosarcoma: A Review
Provisionally accepted
Feipeng Wu
Dapeng LI
*- Affiliated Hospital of Jiangsu University, Zhenjiang, China
YB1 (Y box binding protein 1), a multifunctional protein capable of binding to DNA/RNA, is present in most cells and acts as a splicing factor. It is involved in numerous cellular processes such as transcription, translation, and DNA repair, significantly affecting cell proliferation, differentiation, and apoptosis. Abnormal expression of this protein is closely linked to the formation of various malignancies (osteosarcoma, nasopharyngeal carcinoma, breast cancer, etc.). This review examines the multifaceted functions of YB1 and its critical role in osteosarcoma progression, providing new perspectives for potential therapeutic strategies.
Keywords: Osteosarcoma, splicing factor, YB1, Treatment of osteosarcoma, YBX1 phosphorylation
Received: 03 Jul 2024; Accepted: 07 Oct 2024.
Copyright: © 2024 Wu and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dapeng LI, Affiliated Hospital of Jiangsu University, Zhenjiang, China
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